What is the Zgwatinib?

Zgwatinib is , while it's Molecular Formula is C 22 H 22 F 3 N 5 O 2 . Zgwatinib is a novel, selective c-MET inhibitor, blocking c-MET dependent neoplastic effects and exerting antitumor activity.

What is the CAS number for Zgwatinib?

The CAS number of Zgwatinib is 1268264-10-3.

What is Zgwatinib (1268264-10-3) used for?

Zgwatinib, also known as a c-MET inhibitor, is a pharmaceutical compound designed to selectively target and inhibit the c-MET protein, which plays a crucial role in various cellular processes, including cell proliferation, survival, and migration. By blocking c-MET dependent neoplastic effects, Zgwatinib demonstrates significant antitumor activity, making it a promising candidate for cancer treatment.

What is the Zgwatinib?

Zgwatinib is , while it's Molecular Formula is C 22 H 22 F 3 N 5 O 2 . Zgwatinib is a novel, selective c-MET inhibitor, blocking c-MET dependent neoplastic effects and exerting antitumor activity.

What is the CAS number for Zgwatinib?

The CAS number of Zgwatinib is 1268264-10-3.

What is Zgwatinib (1268264-10-3) used for?

Zgwatinib, also known as a c-MET inhibitor, is a pharmaceutical compound designed to selectively target and inhibit the c-MET protein, which plays a crucial role in various cellular processes, including cell proliferation, survival, and migration. By blocking c-MET dependent neoplastic effects, Zgwatinib demonstrates significant antitumor activity, making it a promising candidate for cancer treatment.

Product classification

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1268264-10-3

Product Name:SOMG-833
Molecular Weight:445.444

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Product Details

Purity:99%

Factory supply SOMG-833 1268264-10-3 with low price

Molecular Formula:C₂₂H₂₂F₃N₅O₂
Molecular Weight:445.444

1268264-10-3 Relevant articles

Synthesis and c-met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: Identification of 3-(4-acetylpiperazin-1-yl)-5- (3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent

Wang, Yuanxiang,Ai, Jing,Wang, Ying,Chen, Yi,Wang, Lu,Liu, Gang,Geng, Meiyu,Zhang, Ao

supporting information; experimental part, p. 2127 - 2142 (2011/06/17)

By use of an improved synthetic strategy...

Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: Key precursors to potent c-Met inhibitors

Wang, Yuanxiang,Ai, Jing,Liu, Gang,Geng, Meiyu,Zhang, Ao

supporting information; experimental part, p. 5930 - 5933 (2011/10/08)

An effective one-pot synthesis of quinol...

1268264-10-3 Process route

: 1332492-87-1
3-(4-methylpiperazin-1-yl)-5-bromo-7-trifluoromethylquinoline

: 26177-43-5
3-nitrobenzylamine hydrochloride

: 1268264-10-3
Zgwatinib

Conditions

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 110 ℃; for 12h; Inert atmosphere;	75%

: 1268264-45-4
C₂₂H₂₀F₃N₅O₂

: 1268264-10-3
Zgwatinib

Conditions

Conditions	Yield
With sodium tetrahydroborate; In ethanol; at 20 ℃; for 1h; Inert atmosphere;

1268264-10-3 Upstream products

109-01-3
1-methyl-piperazine
1268264-34-1
3-bromo-5-nitro-7-trifluoromethylquinoline
1268264-35-2
3-(4-methylpiperazin-1-yl)-5-nitro-7-(trifluoromethyl)quinoline
1268264-36-3
C₁₅H₁₇F₃N₄

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