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pd_meltingpoint:197-199 °C(lit.)
Appearance:Colourless solid
Purity:99%
|
Definition |
ChEBI: A 1,1-bis(phosphonic acid) consisting of methane substituted by two phosphonic acid groups. |
|
General Description |
MDP (Methylenediphosphonic acid) is a phosphonic analog of ATP. |
InChI:InChI=1/CH6O6P2/c2-8(3,4)1-9(5,6)7/h1H2,(H2,2,3,4)(H2,5,6,7)
Studies on the mode of action of a serie...
The acidity of and Li+, Na+, K+, and Cs+...
An alternative approach is reported for ...
The use of readily prepared bisphosphoni...
The synthesis of a conjugate molecule be...
Kinetics studies of dNTP analogues havin...
uridine 5'-(β,γ-methylene)triphosphate
α-D-glucopyranosyl-1-phosphate
UDP-glucose
Methylenediphosphonic acid
| Conditions | Yield |
|---|---|
|
With
Cps2L thymidylyltransferase cloned from Streptococcus pneumoniae; inorganic phosphatase; magnesium chloride;
In
aq. buffer;
pH=7.4;
Kinetics;
Enzymatic reaction;
|
Tetraethyl methylenediphosphonate
Methylenediphosphonic acid
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
1,4-dioxane;
Reflux;
|
98% |
|
Tetraethyl methylenediphosphonate;
With
trimethylsilyl bromide;
In
dichloromethane;
at 20 ℃;
for 15h;
Inert atmosphere;
With
water;
In
methanol;
at 20 ℃;
for 4h;
|
98% |
|
With
trimethylsilyl bromide;
In
1,2-dichloro-ethane;
for 1.5h;
Inert atmosphere;
Reflux;
|
98% |
|
With
hydrogenchloride;
for 16h;
Heating;
|
88% |
|
With
hydrogenchloride;
for 16h;
Heating;
|
88% |
|
With
hydrogenchloride;
for 12h;
Heating;
|
74% |
|
With
hydrogenchloride;
at 120 ℃;
|
|
|
With
hydrogenchloride;
Heating;
|
|
|
With
trimethylsilyl bromide;
In
dichloromethane;
at 20 ℃;
Inert atmosphere;
|
Tetraethyl methylenediphosphonate
P,P'-methanediyl-bis-phosphonic acid tetrachloride
Tetraisopropyl methylenediphosphonate
methylenediphosphonic acid tetrabutyl ester
P,P'-methanediyl-bis-phosphonic acid tetrachloride
Tetraethyl methylenediphosphonate
tetramethyl methylenediphosphonate
Methandiphosphonsaeuretetrapropylester
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