
pd_meltingpoint:200-201 °C
Appearance:Crystalline solid
Purity:99%
Quality products make an important contribution to long-term revenue and profitability. Cyproterone acetate Good Supplier In Bulk Supply High Purity 427-51-0
Cyproterone acetate is a progestational antiandrogen that blocks androgen receptor binding and suppresses androgen-sensitive tissues. It is available in a topical form in Europe for the treatment of hirsutism.
antiparasitic, fasciolicide
6-chloro-17a-acetoxy-pregnane-1,4,6-,triene-3,20-dione
trimethylsulfoxonium iodide
cyproterone acetate
| Conditions | Yield |
|---|---|
|
6-chloro-17a-acetoxy-pregnane-1,4,6-,triene-3,20-dione; trimethylsulfoxonium iodide;
With
sodium hydride;
In
dimethyl sulfoxide;
at 5 - 20 ℃;
for 29.5h;
With
hydrogenchloride;
In
water; dimethyl sulfoxide;
at 0 ℃;
|
51.51% |
C24H30Cl2O4
cyproterone acetate
| Conditions | Yield |
|---|---|
|
With
sodium carbonate;
In
methanol; N,N-dimethyl-formamide;
at 50 - 55 ℃;
for 5h;
|
The CAS number of Cyproterone acetate is 427-51-0.
More information of Cyproterone acetate 427-51-0 are:
|
CAS Number |
427-51-0 |
|
Density |
1.27 g/cm3 |
|
Melting Point |
200-201 °C |
|
Boiling Point |
525.9 °C at 760 mmHg |
|
Flash Point |
177.6 °C |
|
Vapor Pressure |
3.78E-11mmHg at 25°C |
|
Refractive Index |
1.4429 (estimate) |
|
HS CODE |
29372900 |
|
PSA |
60.44000 |
|
LogP |
4.60760 |
Synonyms for Cyproterone acetate 427-51-0:SH 714;Cyproteron-r acetate;6-Chloro-1beta,2beta-dihydro-17-hydroxy-3H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate;Cyproteroneacetate;Cyproterone acetate (JAN/USAN);Cyproviron;1,2-alpha-Methylene-6-chloro-(sup 4,6)-pregnadiene-17-alpha-ol-3,20-dione 17-alpha-acetate;6-Chloro-delta(sup 6)-1,2-alpha-methylene-17-alpha-hydroxyprogesterone acetate;3H-Cyclopropa[1,2]pregna-1,4,6-triene-3, 20-dione, 17- (acetyloxy)-6-chloro-1,2-dihydro-, (1.beta., 2.beta.)-;6-Chloro-delta-6-1,2alpha-methylene-17alpha-hydroxyprogesterone acetate;17-alpha-Acetoxy-6-chloro-1-alpha,2-alpha-methylenepregna-4,6-diene-3,20-dione;1,2-alpha-Methylene-6-chloro-pregna-4,6-diene-3,20-dione 17-alpha-acetate;Cyproterone acetate [USAN:JAN];Cyproterone 17-O-acetate;6-Chloro-1-beta,2-beta-dihydro-17-hydroxy-3H-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione 17-acetate;SH 80714;3H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 6-chloro-1-beta,2-beta-dihydro-17-hydroxy-, acetate;6-Chloro-17-hydroxy-1.alpha.,2.alpha.-methylenepregna-4, 6-diene-3,20-dione acetate;Pregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-1.alpha.,2.alpha.-methylene-, acetate;Cyproterone 17.alpha.-acetate;1, 2.alpha.-Methylene-6-chloro-(sup 4,6)-pregnadiene-17.alpha.-ol-3, 20-dione 17alpha-acetate;Progesterone, 6-chloro-6-dehydro-17-hydroxy-1.alpha.,2.alpha.-methylene-, acetate;Cyproterone 17alpha-acetate;3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20- dione,17-(acetyloxy)-6-chloro-1,2-dihydro-,(1a,2a)-;Cyproteron acetate;Cyprosterone acetate;Androcur;6-chloro-1-β,2-β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione 17-acetate;
The chemical formula of Cyproterone acetate is C24H29ClO4 which containing 24 Carbon atoms,29 Hydrogen atoms,1 Chlorine atoms and 4 Oxygen atoms,and the molecular weight of Cyproterone acetate is 416.945.
Cyproterone acetate (CPA) is an androgen receptor antagonist. It binds to human androgen receptors (Ki = 14 nM) and inhibits dihydrotestosterone-induced androgen receptor activation in CV-1 cells (IC50 = 26 nM). CPA (30 mg/kg) decreases ventral prostate weight in castrated immature rats. It also suppresses accessory sexual glands and fertility in adult male rats when administered at a dose of 10 mg/kg. CPA (0.3 μM) also induces apoptosis in primary adult female rat hepatocytes. Formulations containing cyproterone acetate have been used in the treatment of androgenization in females.
InChI:InChI=1/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14?,15-,16?,17?,18+,22+,23+,24+/m1/s1
Relevant articles related to Cyproterone acetate:
|
Article |
Source |
|
Preparation process of cyproterone acetate (by machine translation) |
- , (2018/09/11) |
|
KIT FOR FEMALE MAMMALS, COMPRISING A COMBINATION OF GESTAGEN AND OESTROGEN |
- , (2008/06/13) |
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