NMS 873 is , while it's Molecular Formula is C 27 H 28 N 4 O 3 S 2 . NMS-873 is a potent and specific VCP inhibitor, which has shown to activate the unfolded protein response, interfere with autophagy and induce cancer cell death.

What is the CAS number for NMS 873?

The CAS number of NMS 873 is 1418013-75-8.

What is NMS 873 (1418013-75-8) used for?

The p97 AAA (ATPase associated with diverse cellular activities) is a ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. Valosin-containing protein (VCP), also known as VCP/p97, is an AAA ATPase family member that serves as an integral component of the ubiquitin fusion degradation pathway and is overexpressed in many tumor types. NMS-873 is a VCP inhibitor (IC50 = 24 nM) that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM). It has been shown to inhibit the proliferation of HCT116 cancer cells with an IC50 value of 380 nM.

NMS 873 is , while it's Molecular Formula is C 27 H 28 N 4 O 3 S 2 . NMS-873 is a potent and specific VCP inhibitor, which has shown to activate the unfolded protein response, interfere with autophagy and induce cancer cell death.

What is the CAS number for NMS 873?

The CAS number of NMS 873 is 1418013-75-8.

What is NMS 873 (1418013-75-8) used for?

The p97 AAA (ATPase associated with diverse cellular activities) is a ubiquitin-selective chaperone known to play a critical role in the degradation of misfolded membrane and secretory proteins and has been linked to various cellular processes that require unfolding and disassembly of protein complexes. Valosin-containing protein (VCP), also known as VCP/p97, is an AAA ATPase family member that serves as an integral component of the ubiquitin fusion degradation pathway and is overexpressed in many tumor types. NMS-873 is a VCP inhibitor (IC50 = 24 nM) that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM). It has been shown to inhibit the proliferation of HCT116 cancer cells with an IC50 value of 380 nM.

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1418013-75-8

Product Name:NMS 873
Molecular Formula:C27H28N4O3S2
Molecular Weight:520.676

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Product Details

Purity:99%

China cas 1418013-75-8 manufacturer wholesale NMS 873 at affordable price

Molecular Formula:C₂₇H₂₈N₄O₃S₂
Molecular Weight:520.676
Boiling Point:769.3±70.0 °C(Predicted)
PKA:2.48±0.12(Predicted)
PSA：120.65000
Density:1.33±0.1 g/cm3(Predicted)
LogP:6.73570

1418013-75-8 Relevant articles

Alkylsulfanyl-1,2,4-triazoles, a New Class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships

Polucci, Paolo,Magnaghi, Paola,Angiolini, Mauro,Asa, Daniela,Avanzi, Nilla,Badari, Alessandra,Bertrand, Jay,Casale, Elena,Cauteruccio, Silvia,Cirla, Alessandra,Cozzi, Liviana,Galvani, Arturo,Jackson, Peter K.,Liu, Yichin,Magnuson, Steven,Malgesini, Beatrice,Nuvoloni, Stefano,Orrenius, Christian,Sirtori, Federico Riccardi,Riceputi, Laura,Rizzi, Simona,Trucchi, Beatrice,O'Brien, Tom,Isacchi, Antonella,Donati, Daniele,D'Alessio, Roberto

, p. 437 - 450 (2013/04/10)

Valosine containing protein (VCP), also ...

1418013-75-8 Process route

: 1418013-41-8
C₂₀H₂₁BrN₄OS

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1418013-75-8
NMS-873

Conditions

Conditions	Yield
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 3h; Microwave irradiation; Inert atmosphere;	40%

: 1418012-77-7
3-(3-benzyloxymethyl-5-cyclopentylsulfanyl[1,2,4]triazol-4-yl)pyridine

: 1418013-75-8
NMS-873

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: boron trichloride / dichloromethane / 2 h / 0 - 5 °C 2: thionyl chloride / dichloromethane / 2 h / 0 - 5 °C 3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C 4: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)CH₂Cl₂ / water; 1,4-dioxane / 3 h / 100 °C / Microwave irradiation; Inert atmosphere With* thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; boron trichloride; potassium carbonate; caesium carbonate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 4: \|Suzuki Coupling;

Yield

Multi-step reaction with 4 steps

1: boron trichloride / dichloromethane / 2 h / 0 - 5 °C

2: thionyl chloride / dichloromethane / 2 h / 0 - 5 °C

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 80 °C

4: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; 1,4-dioxane / 3 h / 100 °C / Microwave irradiation; Inert atmosphere

With thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; boron trichloride; potassium carbonate; caesium carbonate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 4: |Suzuki Coupling;

1418013-75-8 Upstream products

1418012-77-7
3-(3-benzyloxymethyl-5-cyclopentylsulfanyl[1,2,4]triazol-4-yl)pyridine
1418012-78-8
(5-cyclopentylsulfanyl-4-pyridin-3-yl-4H[1,2,4]triazol-3-yl)methanol
1418012-79-9
3-(3-chloromethyl-5-cyclopentylsulfanyl[1,2,4]triazol-4-yl)pyridine
1418012-47-1
5-benzyloxymethyl-4-pyridin-3-yl-4H[1,2,4]triazole-3-thiol

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