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1187595-90-9

Q: What is the CAS number for (4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate?

The CAS number of (4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate is 1187595-90-9.

Product Name:3((4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate)
Molecular Weight:485.567

Inquiry

Product Details

Purity:99%

Factory supply good quality 3((4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate) 1187595-90-9 with stock

Molecular Formula:C₂₂H₂₇N₇O₄S
Molecular Weight:485.567

1187595-90-9 Relevant articles

Preparation of baricitinib and derivative thereof

-

Paragraph 0028-0030, (2021/10/11)

The invention relates to synthesis of ba...

BARICITINIB INTERMEDIATE, METHOD FOR FORMING BARICITINIB INTERMEDIATE, AND METHOD FOR PREPARING BARICITINIB OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

-

, (2019/07/15)

The present disclosure provides a Barici...

Synthesis and Characterization of Compounds Potentially Related to the Janus Kinase Inhibitor Baricitinib

Dasari,Seelam,Jayachandra,Vadali,Yerva,Tondepu,Gadakar

, p. 1569 - 1574 (2019/12/28)

Nine compounds potentially related to th...

METHOD AND INTERMEDIATE FOR THE PRODUCTION OF BARICITINIB

-

Page/Page column 11; 12, (2017/07/14)

Method and intermediates are disclosed f...

1187595-90-9 Process route

: 55052-28-3
4-chloro-7-azaindole

: 1187595-90-9
(4-{1-[3-(cyanomethyl)-1-(ethylsulphonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C 2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 3 h / 72 °C / Inert atmosphere 3: acetyl chloride / methanol / 6 h / 5 - 20 °C 4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 3 h / 5 - 10 °C With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; acetyl chloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
Multi-step reaction with 4 steps 1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C 2: bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; tricyclohexylphosphine; potassium carbonate / water; tert-butyl alcohol / 3 h / 40 °C / Glovebox 3: hydrogenchloride / water; tetrahydrofuran / 6 h / 5 - 20 °C 4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 3 h / 5 - 10 °C With hydrogenchloride; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Yield

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / 1,4-dioxane; water / 3 h / 72 °C / Inert atmosphere

3: acetyl chloride / methanol / 6 h / 5 - 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 3 h / 5 - 10 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; acetyl chloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2: bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; tricyclohexylphosphine; potassium carbonate / water; tert-butyl alcohol / 3 h / 40 °C / Glovebox

3: hydrogenchloride / water; tetrahydrofuran / 6 h / 5 - 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 3 h / 5 - 10 °C

With hydrogenchloride; bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tricyclohexylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;

: (4-{1-[3-(cyanomethyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate

: 1187595-90-9
(4-{1-[3-(cyanomethyl)-1-(ethylsulphonyl)azetidin-3-yl]-1H-pyrazol-4-yl}-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl 2,2-dimethylpropanoate

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; Ethanesulfonyl chloride; In ethyl acetate; at 0 - 20 ℃; for 1.5h; Solvent; Temperature;	95.7%

1187595-90-9 Upstream products

1146629-77-7
[4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl 2,2-dimethylpropanoate
1187595-85-2
2-[1-(ethanesulfonyl)azetidin-3-ylidene]acetonitrile
1153949-11-1
3-(cyanomethylene)azetidine-1-carboxylic acid tert-butyl ester
1146629-76-6
[4-[1-(1-ethoxyethyl)-1H-pyrazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl pivalate

1187595-90-9 Downstream products

1187594-09-7
Baricitinib

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