What is the ALLOPREGNAN-3ALPHA-OL-20-ONE?

ALLOPREGNAN-3ALPHA-OL-20-ONE is , while it's Molecular Formula is C21H34O2. (3α)-Allopregnanolone acts as a GABAA receptor positive allosteric modulator. (3α)-Allopregnanolone is a metabolite of Progesterone (P755900). (3α)-Allopregnanolone is a neuroactive steroid present in the blood and also the brain.

What is the CAS number for ALLOPREGNAN-3ALPHA-OL-20-ONE?

The CAS number of ALLOPREGNAN-3ALPHA-OL-20-ONE is 516-54-1.

What is ALLOPREGNAN-3ALPHA-OL-20-ONE (516-54-1) used for?

Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone . It acts as a positive allosteric modulator of GABAA receptors at nM concentrations (exhibiting the greatest potentiation at isoforms containing δ subunits) and of GABAC receptors at μM concentrations. Allopregnanolone displays effects similar to other GABAA receptor potentiators such as benzodiazepines, including potent anticonvulsant, anxiolytic, and sedative activity.InChI:InChI=1/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1

What is the ALLOPREGNAN-3ALPHA-OL-20-ONE?

ALLOPREGNAN-3ALPHA-OL-20-ONE is , while it's Molecular Formula is C21H34O2. (3α)-Allopregnanolone acts as a GABAA receptor positive allosteric modulator. (3α)-Allopregnanolone is a metabolite of Progesterone (P755900). (3α)-Allopregnanolone is a neuroactive steroid present in the blood and also the brain.

What is the CAS number for ALLOPREGNAN-3ALPHA-OL-20-ONE?

The CAS number of ALLOPREGNAN-3ALPHA-OL-20-ONE is 516-54-1.

What is ALLOPREGNAN-3ALPHA-OL-20-ONE (516-54-1) used for?

Allopregnanolone is an endogenous inhibitory pregnane neurosteroid that is synthesized from progesterone . It acts as a positive allosteric modulator of GABAA receptors at nM concentrations (exhibiting the greatest potentiation at isoforms containing δ subunits) and of GABAC receptors at μM concentrations. Allopregnanolone displays effects similar to other GABAA receptor potentiators such as benzodiazepines, including potent anticonvulsant, anxiolytic, and sedative activity.InChI:InChI=1/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1

Product classification

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516-54-1

Product Name:Allopregnanolone
Molecular Formula:C₂₁H₃₄O₂
Molecular Weight:318.5

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Product Details

pd_meltingpoint:176-178°

Purity:99%

Factory Export Top Purity Allopregnanolone 516-54-1 In Stock

Molecular Formula:C21H34O2
Molecular Weight:318.5
Vapor Pressure:3.05E-09mmHg at 25°C
Melting Point:176-178°
Refractive Index:1.524
Boiling Point:431.2°Cat760mmHg
PKA:15.12±0.70(Predicted)
Flash Point:183.9°C
PSA：37.30000
Density:1.053g/cm³
LogP:4.59520

ALLOPREGNAN-3ALPHA-OL-20-ONE(Cas 516-54-1) Usage

InChI:InChI=1/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1

516-54-1 Relevant articles

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: Role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway

Jin, Yi,Mesaros, A. Clementina,Blair, Ian A.,Penning, Trevor M.

experimental part, p. 53 - 61 (2012/06/15)

Active sex hormones such as testosterone...

METHODS OF NEUROPROTECTION USING NEUROPROTECTIVE STEROIDS AND A VITAMIN D

-

, (2012/01/03)

Described herein are compositions and me...

Reduction of steroidal ketones with amine - Boranes

Leontjev,Vasiljeva,Pivnitsky

, p. 703 - 708 (2007/10/03)

Complexes of secondary amines with boran...

REGIOSELECTIVE REDUCTION OF POLYKETONES ON SILICA GEL SURFACE WITH BORANE-TRIMETHYLAMINE COMPLEX

Gohzu, Shun-ichi,Tada, Masahiro

, p. 61 - 64 (2007/10/02)

Steroidal diones and trione, bicyclic di...

516-54-1 Process route

: 128-23-4
pregnanedione

: 80-89-7,80-90-0,80-92-2,516-53-0,566-56-3,566-57-4,566-58-5,4406-36-4,4479-11-2,4707-80-6,6251-84-9,25908-35-4,28818-70-4,36027-66-4,38270-91-6,38270-97-2,52746-43-7,55569-11-4,55660-10-1,73745-18-3,98048-13-6,80-91-1
pregnadiol

: 128-20-1,128-21-2,516-54-1,516-55-2,4243-94-1,4320-08-5,4406-35-3,4406-37-5,4469-03-8,13089-85-5,13089-86-6,14615-01-1,21788-58-9,24557-99-1,25126-79-8,26961-00-2,36027-63-1,39845-99-3,40135-22-6,72691-57-7,81076-02-0,95118-68-6,110350-90-8
PREGNANOLONE

Conditions

Conditions	Yield
With recombinant human aldo-keto reductase 1C₃; NADPH; In methanol; at 37 ℃; for 1.5h; pH=7; stereospecific reaction; aq. phosphate buffer; Enzymatic reaction;

: 57-83-0
Progesterone

: 128-23-4
pregnanedione

: 128-21-2
3β-hydroxy-5β-pregnan-20-one

: 80-92-2
pregnanediol

: 80-89-7,80-90-0,80-92-2,516-53-0,566-56-3,566-57-4,566-58-5,4406-36-4,4479-11-2,4707-80-6,6251-84-9,25908-35-4,28818-70-4,36027-66-4,38270-91-6,38270-97-2,52746-43-7,55569-11-4,55660-10-1,73745-18-3,98048-13-6,80-91-1
pregnadiol

: 128-20-1,128-21-2,516-54-1,516-55-2,4243-94-1,4320-08-5,4406-35-3,4406-37-5,4469-03-8,13089-85-5,13089-86-6,14615-01-1,21788-58-9,24557-99-1,25126-79-8,26961-00-2,36027-63-1,39845-99-3,40135-22-6,72691-57-7,81076-02-0,95118-68-6,110350-90-8
PREGNANOLONE

: 31329-54-1
3α-hydroxy-5β-pregnane-20-one-3-glucuronide

Conditions

Conditions	Yield
With phosphate buffer; (S)-2-[3]pyridyl-pyrrolidine-1-carboxylic acid amide; α-D-glucose 6-phosphate; bovine liver tissue supernatant; NADP; UDP-glucuronic acid; at 37 ℃; for 5h; Product distribution; <14C>labeled;	4 % Chromat. 1 % Chromat. 22 % Chromat. 15 % Chromat. 46 % Chromat.

516-54-1 Upstream products

566-65-4
dihydroprogesterone
57-83-0
Progesterone
10035-10-6
hydrogen bromide
64-19-7
acetic acid

516-54-1 Downstream products

906-83-2
Pregnanolon-3β-acetat
566-65-4
dihydroprogesterone
1852-53-5
androstanediol
440368-51-4
3α-(tert-butyldiphenylsilyloxy)-5α-androstan-17β-carboxaldehyde

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