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4991-65-5

  • Product Name:Tioxolone
  • Molecular Formula:C7H4O3S
  • Molecular Weight:168.173
  • Appearance:light yellow to beige powder
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Product Details

pd_meltingpoint:158-160 °C(lit.)

Appearance:light yellow to beige powder

Purity:99%

Reliable factory customized supply Tioxolone 4991-65-5

  • Molecular Formula:C7H4O3S
  • Molecular Weight:168.173
  • Appearance/Colour:light yellow to beige powder 
  • Vapor Pressure:3.02E-06mmHg at 25°C 
  • Melting Point:158-160 °C(lit.) 
  • Refractive Index:1.718 
  • Boiling Point:377.8 °C at 760 mmHg 
  • PKA:8.14±0.20(Predicted) 
  • Flash Point:182.3 °C 
  • PSA：78.68000 
  • Density:1.617 g/cm3 
  • LogP:1.56010 

Tioxolone(Cas 4991-65-5) Usage

Manufacturing Process

40 g potassium thiocyanate in 50 ml of water are added, while stirring at room temperature, to a solution of 11 g of resorcinol and 50 g of crystallized copper sulfate in 250 ml of water. The black cupric thiocyanate formed becomes colorless after a short time, which indicates that the introduction of thiocyanogen is terminated. The cuprous thiocyanate is removed by filtering with suction and then washed with water; the filtrate is mixed with 50 ml of a 2 N sodium carbonate solution, whereby the imino-thiocarbonate of resorcinol separates in the form of a colorless crystalline body. The yield amounts to 16 g. The new compound which melts at 149°C dissolves very easily in many organic solvents and in mineral acids. A 10% solution of the imino-thiocarbonate of resorcinol in 10% hydrochloric acid is heated for 15 min on the steam bath. The 6-hydroxy-1,3-benzoxathiol- 2-one (thiocarbonate free from) nitrogen separates, on cooling, in the form of fine crystals melting at 158°C.

Therapeutic Function

Antiseborreic, Antifungal, Keratolytic

Definition

ChEBI: A 1,3-benzoxathiole having a hydroxy substituent at the 6-position.

General Description

Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one has been investigated. Supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one has been studied.

InChI:InChI=1/C7H4O3S/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3,8H

4991-65-5 Relevant articles

Benzo[d][1,3] oxathiols: Synthesis and biological evaluation as potential atypical antipsychotic agents

Dash, Radha Charan,Suryawanshi, Mugdha R.,Shelke, Suhas M.,Bhosale, Sharad H.,Mahadik, Kakasaheb R.

experimental part, p. 29 - 35 (2012/02/04)

The present research paper reports the s...

4991-65-5 Process route

2-iminobenzo[d][1,3]oxathiol-6-ol

2-iminobenzo[d][1,3]oxathiol-6-ol

tioxolone
4991-65-5

tioxolone

Conditions
Conditions Yield
With hydrogenchloride; In water; for 0.25h; Heating;
89%
ammonium thiocyanate
1147550-11-5

ammonium thiocyanate

recorcinol
108-46-3

recorcinol

tioxolone
4991-65-5

tioxolone

Conditions
Conditions Yield
With water; copper(II) sulfate; anschliessend Erwaermen;

4991-65-5 Upstream products

  • 1147550-11-5
    1147550-11-5

    ammonium thiocyanate

  • 108-46-3
    108-46-3

    recorcinol

  • 7732-18-5
    7732-18-5

    water

  • 7758-99-8
    7758-99-8

    copper(II) sulfate

4991-65-5 Downstream products

  • 2553-70-0
    2553-70-0

    2,4-dihydroxythiophenol

  • 288589-43-5
    288589-43-5

    (S)-2-(2-Hydroxy-4-methoxy-5-methylsulfanyl-benzylamino)-propionic acid

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