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pd_meltingpoint:230-233 oC
Purity:99%
Optimization of a new series of S-adenos...
The invention provides a therapeutic dru...
tert‐butyl (2,3‐dihydro‐1H‐inden‐2‐yl)carbamate
N-methylindan-2-amine hydrochloride
| Conditions | Yield |
|---|---|
|
tert‐butyl (2,3‐dihydro‐1H‐inden‐2‐yl)carbamate;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 3h;
Reflux;
With
hydrogenchloride;
In
1,4-dioxane; diethyl ether;
at 20 ℃;
|
3.53 g |
2,3-dihydro-1H-inden-2-amine
N-methylindan-2-amine hydrochloride
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 2 h / 20 °C / Cooling with ice
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Reflux
2.2: 20 °C
With
lithium aluminium tetrahydride; triethylamine;
In
tetrahydrofuran; dichloromethane;
|
2,3-dihydro-1H-inden-2-amine
N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-{2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl}-N1-(3-pyrrolidin-1-ylpropyl)glycinamide
N2-[5-chloro-2-(4-chlorophenoxy)phenyl]-N2-{2-[2,3-dihydro-1H-inden-2-yl(methyl)amino]-2-oxoethyl}-N1-(2-pyrrolidin-1-ylethyl)glycinamide
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