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Purity:99%
The present invention provides compounds...
An efficient Pd(0)-catalyzed Buchwald-Ha...
4-(4-fluorophenyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester
1-(4-fluorophenyl)-1,4-diazepane hydrochloride salt
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride;
In
methanol;
at 5 - 10 ℃;
|
90% |
|
With
hydrogenchloride;
In
1,4-dioxane; diethyl ether;
at 20 ℃;
for 3h;
|
89% |
tert-butyl 1,4-diazepine-1-carboxylate
1-Bromo-4-fluorobenzene
1-(4-fluorophenyl)-1,4-diazepane hydrochloride salt
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 2 steps
1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 17 h / 80 °C
2: hydrogenchloride / 1,4-dioxane; diethyl ether / 3 h / 20 °C
With
hydrogenchloride; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate;
In
1,4-dioxane; diethyl ether; toluene;
|
4-(4-fluorophenyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester
tert-butyl 1,4-diazepine-1-carboxylate
1-Bromo-4-fluorobenzene
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