What is the Nepicastat hydrochloride?

Nepicastat hydrochloride is , while it's Molecular Formula is C14H15 F2 N3 S . Cl H. Nepicastat Hydrochloride is a potent and selective dopamine β-hydrolase inhibitor. Used in cardiovascular treatment where deficiencies in ventricles results in heart failure.

What is the CAS number for Nepicastat hydrochloride?

The CAS number of Nepicastat hydrochloride is 170151-24-3.

What is Nepicastat hydrochloride (170151-24-3) used for?

Nepicastat is an inhibitor of dopamine β-hydroxylase (DBH; IC50 = 9 nM for the purified human enzyme). It is selective for DBH over a panel of 12 enzymes and 13 neurotransmitter receptors (IC50s or Kis = >10 μM). Nepicastat dose-dependently reduces norepinephrine content and increases dopamine content in the mesenteric artery, left ventricle, and cerebral cortex in spontaneously hypertensive rats, as well as in the renal artery, left ventricle, and cerebral cortex in beagle dogs. It attenuates increases in diastolic blood pressure and heart rate induced by preganglionic sympathetic nerve stimulation in pithed spontaneously hypertensive rats when administered orally at doses of 10 and 30 mg/kg. Nepicatstat (50 mg/kg) reduces the progressive ratio response for cocaine, but not food or sucrose pellets, in rats. It also reduces reinstatement of cocaine-seeking behavior induced by cues, yohimbine , or foot-shock in rats.

What is the Nepicastat hydrochloride?

Nepicastat hydrochloride is , while it's Molecular Formula is C14H15 F2 N3 S . Cl H. Nepicastat Hydrochloride is a potent and selective dopamine β-hydrolase inhibitor. Used in cardiovascular treatment where deficiencies in ventricles results in heart failure.

What is the CAS number for Nepicastat hydrochloride?

The CAS number of Nepicastat hydrochloride is 170151-24-3.

What is Nepicastat hydrochloride (170151-24-3) used for?

Nepicastat is an inhibitor of dopamine β-hydroxylase (DBH; IC50 = 9 nM for the purified human enzyme). It is selective for DBH over a panel of 12 enzymes and 13 neurotransmitter receptors (IC50s or Kis = >10 μM). Nepicastat dose-dependently reduces norepinephrine content and increases dopamine content in the mesenteric artery, left ventricle, and cerebral cortex in spontaneously hypertensive rats, as well as in the renal artery, left ventricle, and cerebral cortex in beagle dogs. It attenuates increases in diastolic blood pressure and heart rate induced by preganglionic sympathetic nerve stimulation in pithed spontaneously hypertensive rats when administered orally at doses of 10 and 30 mg/kg. Nepicatstat (50 mg/kg) reduces the progressive ratio response for cocaine, but not food or sucrose pellets, in rats. It also reduces reinstatement of cocaine-seeking behavior induced by cues, yohimbine , or foot-shock in rats.

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170151-24-3

Product Name:Nepicastat HCl
Molecular Formula:C14H15 F2 N3 S . Cl H
Molecular Weight:331.81752

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Product Details

Purity:99%

Reliable Quality Nepicastat HCl 170151-24-3 Hot Sale with Chinese Manufacturer

Molecular Formula:C14H15 F2 N3 S . Cl H
Molecular Weight:331.81752
PSA：78.83000
LogP:4.51490

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