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pd_meltingpoint:78 °C
Purity:99%
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ROTIGOTINE is , while it's Molecular Formula is C19H25NOS. It is a non-ergot dopamine agonist drug and is indicated for the treatment of Parkinson disease.
The CAS number of ROTIGOTINE is 99755-59-6.
More information of ROTIGOTINE 99755-59-6 are:
|
Synonyms |
Rotigotine; |
|
CAS Number |
99755-59-6 |
|
Molecular Formula |
C19H25NOS |
|
Molecular Weight |
315.48 |
|
Density |
1.15 g/cm3 |
|
Melting Point |
78 °C |
|
Boiling Point |
470.1 °C at 760 mmHg |
|
Flash Point |
238.1 °C |
|
HS CODE |
2934990002 |
|
PSA |
51.71000 |
|
LogP |
4.26570 |
|
Pka |
10.49±0.40(Predicted) |
Rotigotine is a non-selective dopamine receptor agonist with pEC50 values of 9.6, 10.4, 8.2, 7.7, and 7.7 for D1, D2, D3, D4, and D5, respectively. It demonstrates a high-affinity for D1, D2, and D3 with lesser affinity for D4 and D5 receptor subtypes. This binding profile is similar to that of apomorphine and pergolide but differentiated from that of pramipexole and ropinirole, which have a more narrow profile of receptor specificity. Each of these agonists demonstrates anti-Parkinsonian effects in animal and clinical models through their ability to directly activate dopamine receptors.
InChI:InChI=1/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7,13,16,21H,2,8-12,14H2,1H3/t16-/m0/s1
Articles related to ROTIGOTINE:
|
Article |
Source |
|
Preparation method of rotigotine |
- Paragraph 0069-0071, (2021/08/11) |
|
Preparation method for rotigotine |
- Paragraph 0061; 0170; 0206-0212; 0218, (2019/04/17) |
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