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122341-38-2

  • Product Name:Temoporfin
  • Molecular Formula:C44H32N4O4
  • Molecular Weight:680.762
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Product Details

pd_meltingpoint:>250 °C

Purity:99%

Factory supply good quality Temoporfin 122341-38-2 with stock

  • Molecular Formula:C44H32N4O4
  • Molecular Weight:680.762
  • Melting Point:>250 °C 
  • Refractive Index:1.734 
  • PSA：137.22000 
  • Density:1.386 g/cm3 
  • LogP:5.91260 

Temoporfin(Cas 122341-38-2) Usage

General Description

Temoporfin (mTHPC) is a second-generation photosensitizer used in photodynamic therapy (PDT), known for its amphiphilic properties and efficacy in targeting tumors. It belongs to the chlorin class, specifically as a derivative of 5,10,15,20-tetrakis(m-hydroxyphenyl)chlorin, and has been modified to optimize its localization and photodynamic activity. Temoporfin's structure allows for mixed hydrophilic/hydrophobic substitution patterns, enhancing its suitability for PDT applications. Research has focused on synthesizing related porphyrins to improve photosensitizer performance, leveraging methods like condensation and transition metal-catalyzed coupling. Temoporfin's derivatives are characterized for their potential in PDT, emphasizing their role in advancing therapeutic precision.

Brand name

Foscan

InChI:InChI=1/C44H32N4O4/c49-29-9-1-5-25(21-29)41-33-13-15-35(45-33)42(26-6-2-10-30(50)22-26)37-17-19-39(47-37)44(28-8-4-12-32(52)24-28)40-20-18-38(48-40)43(36-16-14-34(41)46-36)27-7-3-11-31(51)23-27/h1-17,19,21-24,46-47,49-52H,18,20H2/b41-33-,41-34-,42-35-,42-37-,43-36-,43-38-,44-39-,44-40-

122341-38-2 Relevant articles

Photobleaching of Compounds of the 5,10,15,20-Tetrakis(m-hydroxyphenyl)-porphyrin Series (m-THPP, m-THPC, and m-THPBC)

Bonnett, Raymond,Martinez, Gabriel

, p. 2013 - 2016 (2002)

(Matrix Presented) 5,10,15,20-Tetrakis(m...

Photodynamic therapy efficacy enhanced by dynamics: The role of charge transfer and photostability in the selection of photosensitizers

Arnaut, Luis G.,Pereira, Mariette M.,Dabrowski, Janusz M.,Silva, Elsa F. F.,Schaberle, Fabio A.,Abreu, Artur R.,Rocha, Luis B.,Barsan, Madalina M.,Urbanska, Krystyna,Stochel, Grazyna,Brett, Christopher M. A.

, p. 5346 - 5357 (2014)

Progress in the photodynamic therapy (PD...

MnO2 instead of quinones as selective oxidant of tetrapyrrolic macrocycles

Nascimento, Bruno F.O.,Rocha Gonsalves, António M.d'A.,Pineiro, Marta

experimental part, p. 395 - 398 (2010/06/12)

Porphyrins and chlorins were generated t...

122341-38-2 Process route

methanol
67-56-1

methanol

Temoporfin

Temoporfin

Succinimide
123-56-8,89963-74-6

Succinimide

methyl 3-hydroxybenzoate
19438-10-9

methyl 3-hydroxybenzoate

temoporfin
122341-38-2

temoporfin

7,8-dihydro-1,9-bis(3-hydroxybenzoyl)-5-(3-hydroxyphenyl)pyrromethene

7,8-dihydro-1,9-bis(3-hydroxybenzoyl)-5-(3-hydroxyphenyl)pyrromethene

Conditions
Conditions Yield
With air; In methanol; for 5.3h; Product distribution; Photolysis;
meso-5,10,15,20-tetra(3-hydroxyphenyl)porphine
22112-79-4

meso-5,10,15,20-tetra(3-hydroxyphenyl)porphine

temoporfin
122341-38-2

temoporfin

Conditions
Conditions Yield
meso-5,10,15,20-tetra(3-hydroxyphenyl)porphine; With toluene-4-sulfonic acid hydrazide; at 140 ℃; for 0.25h; Inert atmosphere; Schlenk technique;
With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In methanol; dichloromethane; Inert atmosphere;
60%

122341-38-2 Upstream products

  • 67-56-1
    67-56-1

    methanol

  • 22112-79-4
    22112-79-4

    meso-5,10,15,20-tetra(3-hydroxyphenyl)porphine

  • 100-83-4
    100-83-4

    meta-hydroxybenzaldehyde

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