What is the Dantrolene sodium salt?

Dantrolene sodium salt is COA, while it's Molecular Formula is C14H9N4O5Na. COA Dantrolene Sodium Salt is a skeletal muscle relaxant, which inhibits intracellular Ca 2+release from the sarcoplasmic reticulum.

What is the CAS number for Dantrolene sodium salt?

The CAS number of Dantrolene sodium salt is 14663-23-1.

What is Dantrolene sodium salt (14663-23-1) used for?

Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 μM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 μM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 μM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 μg/ml) and MHS pigs (ED50 = 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.InChI:InChI=1/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/b15-7+;

What is the Dantrolene sodium salt?

Dantrolene sodium salt is COA, while it's Molecular Formula is C14H9N4O5Na. COA Dantrolene Sodium Salt is a skeletal muscle relaxant, which inhibits intracellular Ca 2+release from the sarcoplasmic reticulum.

What is the CAS number for Dantrolene sodium salt?

The CAS number of Dantrolene sodium salt is 14663-23-1.

What is Dantrolene sodium salt (14663-23-1) used for?

Dantrolene is an inhibitor of calcium release from the sarcoplasmic reticulum (IC50 = 0.3 μM). It binds to sarcoplasmic reticulum vesicles isolated from normal and malignant hyperthermia-susceptible (MHS) pigs with Kd values of 0.3 and 0.09 μM, respectively. Dantrolene reduces spontaneous calcium wave frequency and amplitude in the presence of calmodulin in isolated mouse cardiomyocytes with IC50 values of 0.42 and 0.19 μM, respectively. It reduces the magnitude of electrically stimulated twitch tensions in isolated rat extensor digitorum longus and soleus muscles (IC50 = 3 μg/ml) and MHS pigs (ED50 = 0.85 mg/kg). Formulations containing dantrolene have been used in the treatment of malignant hyperthermia.InChI:InChI=1/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/b15-7+;

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14663-23-1

Product Name:Dantrolene sodium salt
Molecular Formula:C₁₄H₉N₄O₅Na
Molecular Weight:336.239
Appearance:COA

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Product Details

Appearance:COA

Purity:99%

Manufacturer Supply Best Quality Dantrolene sodium salt 14663-23-1 with Efficient Transportation

Molecular Formula:C14H9N4O5Na
Molecular Weight:336.239
Appearance/Colour:COA
Boiling Point:85°C 4mm
Flash Point:283.1oC
PSA：127.05000
LogP:1.71410

Dantrolene sodium salt(Cas 14663-23-1) Usage

Biological Activity	Inhibits release of Ca 2+ from sarcoplasmic reticulum via inhibition of ryanodine receptor (RYR) channels. Displays selectivity for RYR1 and RYR3 over RYR2. Protective against the effects of a variety of conditions and agents, including excitatory amino acids. Skeletal muscle relaxant and neuroprotectant.
Definition	ChEBI: The anhydrous sodium salt of dantrolene.
Brand name	Dantrium (Procter & Gamble).

InChI:InChI=1/C14H10N4O5.Na/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;/h1-7H,8H2,(H,16,19,20);/b15-7+;

14663-23-1 Relevant articles

SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF DANTROLENE AND SODIUM DANTROLENE

Oleinik, A. F.,Andreeva, N. I.,Syubaev, R. D.,Golovina, S. M.,Vozyakova, T. I.

, p. 310 - 312 (2007/10/02)

14663-23-1 Process route

: 7261-97-4
dantrolene

: 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt

Conditions

Conditions	Yield
With sodium methylate; In methanol; at 20 ℃; for 3h;	100%

: 7147-77-5
5-(4-nitrophenyl)-2-furaldehyde

: 14663-23-1
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 81 percent / H₂O; dimethylformamide 2: 100 percent / CH₃ONa / methanol / 3 h / 20 °C With sodium methylate; In methanol; water; N,N-dimethyl-formamide;

14663-23-1 Upstream products

7261-97-4
dantrolene
7147-77-5
5-(4-nitrophenyl)-2-furaldehyde

14663-23-1 Downstream products

7261-97-4
dantrolene

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