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305-03-3

  • Product Name:Chlorambucil
  • Molecular Formula:C14H19Cl2NO2
  • Molecular Weight:304.216
  • Appearance:beige powder
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Product Details

pd_meltingpoint:65-70 °C

Appearance:beige powder

Purity:99%

Offer Chemical Raw Material Chlorambucil 305-03-3 In Stock

  • Molecular Formula:C14H19Cl2NO2
  • Molecular Weight:304.216
  • Appearance/Colour:beige powder 
  • Vapor Pressure:2.98E-09mmHg at 25°C 
  • Melting Point:65-70 °C 
  • Refractive Index:1.536 
  • Boiling Point:460.09 °C at 760 mmHg 
  • Flash Point:232.054 °C 
  • PSA：40.54000 
  • Density:1.248 g/cm3 
  • LogP:3.37790 

305-03-3(Cas 305-03-3) Usage

General Description

Chlorambucil (305-03-3) is an alkylating anticancer agent that was studied as part of a "switch off/switch on" drug delivery system, where its cytotoxicity was modulated by conjugation to a bi-nuclear amino acid platform (MAAP) and subsequent release via a cell-targeting peptide. This approach demonstrated controlled activation of its therapeutic effects, enhancing specificity for cancer cells while minimizing off-target toxicity. The study highlighted its potential as part of a versatile drug-carrier system for targeted chemotherapy.

InChI:InChI=1/C15H20Cl2O2/c16-10-8-14(9-11-17)13-6-4-12(5-7-13)2-1-3-15(18)19/h4-7,14H,1-3,8-11H2,(H,18,19)

305-03-3 Relevant articles

A two-photon responsive naphthyl tagged: P -hydroxyphenacyl based drug delivery system: Uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring

Kundu, Moumita,Mondal, Mahitosh,Nair, Asha V,Pal, Bipul,Roy, Biswajit,Roy, Samrat,Shah, Sk. Sheriff,Singh, Amit Kumar,Singh, N. D. Pradeep

, p. 9986 - 9989 (2020)

We report a two-photon responsive drug d...

Upconversion-like Photolysis of BODIPY-Based Prodrugs via a One-Photon Process

Lv, Wen,Li, Yafei,Li, Feiyang,Lan, Xin,Zhang, Yaming,Du, Lili,Zhao, Qiang,Phillips, David L.,Wang, Weiping

, p. 17482 - 17486 (2019)

Photochemical reactions at lower energy ...

Single component photoresponsive fluorescent organic nanoparticles: a smart platform for improved biomedical and agrochemical applications

Chaudhuri, Amrita,Paul, Amrita,Sikder, Antara,Pradeep Singh

, p. 1715 - 1733 (2021)

In the last two decades, light responsiv...

Three-Arm, Biotin-Tagged Carbazole–Dicyanovinyl–Chlorambucil Conjugate: Simultaneous Tumor Targeting, Sensing, and Photoresponsive Anticancer Drug Delivery

Venkatesh, Yarra,Karthik,Rajesh,Mandal, Mahitosh,Jana, Avijit,Singh, N. D. Pradeep

, p. 3482 - 3486 (2016)

The design, synthesis, and in vitro biol...

Targeted photoresponsive carbazole–coumarin and drug conjugates for efficient combination therapy in leukemia cancer cells

Chang, Wen-Wei,Chu, Chih-Chien,Lai, Yi-Ting,Lin, Yen-Cheng,Ou, Jia-Yu,Wang, Bing-Yen

, (2020)

Phototriggered drug delivery systems (PT...

A dual-analyte probe: Hypoxia activated nitric oxide detection with phototriggered drug release ability

Biswas, Sandipan,Rajesh,Barman, Shrabani,Bera, Manoranjan,Paul, Amrita,Mandal, Mahitosh,Pradeep Singh

, p. 7940 - 7943 (2018)

A new strategy for the detection of hypo...

PHOTOLYTIC COMPOUNDS AND TRIPLET-TRIPLET ANNIHILATION MEDIATED PHOTOLYSIS

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Paragraph 0026; 00254, (2021/04/17)

The invention provides novel photolytic ...

Method for synthesizing chlorambucil

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Paragraph 0028; 0031-0032; 0035-0036, (2021/07/17)

The invention discloses a method for syn...

Cys fluorescent molecular probe for detecting DNA targeting under reduction stress as well as preparation method and application of Cys fluorescent molecular probe

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Paragraph 0067-0068, (2021/06/26)

The invention relates to a Cys fluoresce...

305-03-3 Process route

(E)-2-(6-(2-((3-(3,4-dihydroxyphenyl)acryloyl)oxy)acetyl)-9-ethyl-9H-carbazol-3-yl)-2-oxoethyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

(E)-2-(6-(2-((3-(3,4-dihydroxyphenyl)acryloyl)oxy)acetyl)-9-ethyl-9H-carbazol-3-yl)-2-oxoethyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

caffeic acid
331-39-5,501-16-6

caffeic acid

2-(9-ethyl-9H-carbazol-3-yl)-2-oxoethyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

2-(9-ethyl-9H-carbazol-3-yl)-2-oxoethyl 4-(4-(bis(2-chloroethyl)amino)phenyl)butanoate

3,6-bis(hydroxyacetyl)-9-ethyl-9H-carbazole

3,6-bis(hydroxyacetyl)-9-ethyl-9H-carbazole

chlorambucil
305-03-3

chlorambucil

Conditions
Conditions Yield
In water; acetonitrile; for 1h; UV-irradiation;
C<sub>19</sub>H<sub>31</sub>Cl<sub>2</sub>N<sub>2</sub>O<sub>2</sub><sup>(1+)</sup>*Cl<sup>(1-)</sup>

C19H31Cl2N2O2(1+)*Cl(1-)

choline chloride
67-48-1

choline chloride

chlorambucil
305-03-3

chlorambucil

Conditions
Conditions Yield
With equine serum butyrylcholinesterase; Enzymatic reaction;

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