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pd_meltingpoint:78-80°C
Purity:99%
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Veterinary Drugs and Treatments |
Firocoxib is indicated in dogs and horses for the control of pain and inflammation associated with osteoarthritis. A chewable tablet form for dogs and an oral paste for horses are available. Like other NSAIDs, firocoxib can be useful for treating fever, pain, and/or inflammation associated with other conditions, postsurgery, trauma, etc. Firocoxib may also be useful in other species, but information is scant regarding its safety and efficacy. One study in cats (McCann, Rickes et al. 2005) evaluating firocoxib in experimentally induced pyrexia, demonstrated that the drug was effective after a single oral dose in preventing or attenuating pyrexia at all doses studied (0.75 – 3 mg/kg). |
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Definition |
ChEBI: An enol ether that is the cyclopropylmethyl ether of 3-hydroxy-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2-one. A selective cyclooxygenase 2 inhibitor, it is used in veterinary medicine for the control of pain and inflammation associated with osteoart ritis in horses and dogs. |
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Brand name |
Equioxx (Merial). |
InChI:InChI=1/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3
The invention relates to a preparation m...
The invention relates to the technical f...
The invention relates to the technical f...
The invention relates to a preparation m...
(4-methylsulfanylphenyl)oxoacetic acid ethyl ester
3-(Cyclopropylmethoxy)-5.5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one
| Conditions | Yield |
|---|---|
|
Multi-step reaction with 5 steps
1.1: oxone||potassium monopersulfate triple salt / water; Isopropyl acetate / 48 h / 20 °C
2.1: toluene-4-sulfonic acid; ethylene glycol / toluene / 6 h / 110 °C
2.2: 10 h / 5 - 20 °C
2.3: 3 h
3.1: triethylamine / dichloromethane / 4 h / 20 °C
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 12 h / Reflux
5.1: tetrabutylammomium bromide; sodium hydroxide / toluene / 48 h / 75 - 80 °C
With
oxone||potassium monopersulfate triple salt; tetrabutylammomium bromide; toluene-4-sulfonic acid; ethylene glycol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide;
In
dichloromethane; Isopropyl acetate; water; toluene; acetonitrile;
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![2-cyclopropylmethoxyacetic acid [1,1-dimethyl-2-(4-methanesulfonylphenyl)-2-oxoethyl]ester](/upload/2025/4/d063f743-89c9-44b6-9b4f-4634eb297ea3.png)
2-cyclopropylmethoxyacetic acid [1,1-dimethyl-2-(4-methanesulfonylphenyl)-2-oxoethyl]ester
3-(Cyclopropylmethoxy)-5.5-dimethyl-4-(4-(methylsulfonyl)phenyl)-5H-furan-2-one
| Conditions | Yield |
|---|---|
|
With
isopropyl Trifluoroacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
acetonitrile;
for 12h;
Reflux;
|
94% |
|
With
isopropyl Trifluoroacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
N,N-dimethyl-formamide;
at 80 - 100 ℃;
Inert atmosphere;
|
77% |
|
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
acetonitrile;
|
|
|
With
isopropyl Trifluoroacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
toluene;
at 95 ℃;
for 12h;
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4.78 g |
2-cyclopropylmethoxyacetic acid [1,1-dimethyl-2-(4-methanesulfonylphenyl)-2-oxoethyl]ester
methyl-phenyl-thioether
2-methyl-1-(4-(methylthio)phenyl)-propan-1-one
2-hydroxy-2-methyl-1-(4-(methylthio)phenyl)-propan-1-one
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