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75621-03-3

  • Product Name:CHAPS
  • Molecular Formula:C32H58N2O7S
  • Molecular Weight:614.888
  • Appearance:white crystalline powder
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Product Details

pd_meltingpoint:156-158 °C (dec.)

Appearance:white crystalline powder

Purity:99%

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  • Molecular Formula:C32H58N2O7S
  • Molecular Weight:614.888
  • Appearance/Colour:white crystalline powder 
  • Melting Point:156-158 °C (dec.) 
  • Refractive Index:1.6900 (estimate) 
  • PSA：155.37000 
  • Density:1.01 g/mL at 20 °C 
  • LogP:4.35380 

3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate(Cas 75621-03-3) Usage

Biological Activity

CHAPS is a zwitterionic nondenaturing detergent for solubilizing membrane proteins. Combines the properties of both the sulfobetaine-type and bile-acid detergents.

Application

CHAPS is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons. CHAPS detergent is non-denaturing to membrane proteins, can solubilize proteins, disaggregate protein-protein interactions. CHAPS is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. It is suitable for isolation of membrane proteins with the following features such as sufficient protein solubilization capability, no denaturing or inactivation of proteins, no interference with protein activities, no precipitation at 4°C, appropriate critical micelle concentrations (CMC) and micelle size, no absorption in the UV region, no toxicity and availability of detergent detection methods.

General Description

CHAPS is a stabilizing agent that can be used to prevent aggregation, precipitation or proteolysis of proteins in solution.

InChI:InChI=1/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)/t21-,22+,23-,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1

75621-03-3 Relevant articles

A Switchable Open/closed Polyaromatic Macrocycle that Shows Reversible Binding of Long Hydrophilic Molecules

Kurihara, Kohei,Yazaki, Kohei,Akita, Munetaka,Yoshizawa, Michito

, p. 11360 - 11364 (2017)

In spite of wide-ranging previous studie...

75621-03-3 Process route

C<sub>88</sub>H<sub>56</sub>N<sub>4</sub><sup>(4+)</sup>*4Cl<sup>(1-)</sup>*C<sub>32</sub>H<sub>58</sub>N<sub>2</sub>O<sub>7</sub>S

C88H56N4(4+)*4Cl(1-)*C32H58N2O7S

C<sub>88</sub>H<sub>60</sub>N<sub>4</sub>O<sub>4</sub>

C88H60N4O4

3-[(3-cholamidopropyl)dimethylammonio]propanesulfonate
75621-03-3

3-[(3-cholamidopropyl)dimethylammonio]propanesulfonate

Conditions
Conditions Yield
With water; sodium hydrogencarbonate; at 20 ℃;
C<sub>88</sub>H<sub>56</sub>N<sub>4</sub><sup>(4+)</sup>*4Cl<sup>(1-)</sup>

C88H56N4(4+)*4Cl(1-)

3-[(3-cholamidopropyl)dimethylammonio]propanesulfonate
75621-03-3

3-[(3-cholamidopropyl)dimethylammonio]propanesulfonate

C<sub>88</sub>H<sub>56</sub>N<sub>4</sub><sup>(4+)</sup>*4Cl<sup>(1-)</sup>*C<sub>32</sub>H<sub>58</sub>N<sub>2</sub>O<sub>7</sub>S

C88H56N4(4+)*4Cl(1-)*C32H58N2O7S

Conditions
Conditions Yield
In water-d2; at 20 ℃; for 0.166667h;
100%

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