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865305-30-2

Q: What is the 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-?

2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]- is , while it's Molecular Formula is C14H17IN4O2. Used in Pharmaceutical Industry: 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]is used as a pharmaceutical agent for its potential therapeutic effects. 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-'s unique structure allows it to interact with specific biological targets, such as receptors or enzymes, modulating their activity and leading to desired pharmacological effects. Used in Chemical Research: In the field of chemical research, 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]serves as a valuable compound for studying the structure-activity relationships of various biologically active molecules. Its unique features can provide insights into the design and development of new drugs and other bioactive compounds. Used in Material Science: 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]can also be utilized in material science for the development of novel materials with specific properties. Its unique structure and functional groups can be exploited to create materials with tailored characteristics for various applications, such as sensors, catalysts, or advanced materials for electronics and energy storage.

Q: What is the CAS number for 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-?

The CAS number of 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]- is 865305-30-2.

Q: What is 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]- (865305-30-2) used for?

AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 μM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats.

Product Name:2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
Molecular Formula:C14H17IN4O2
Molecular Weight:400.219

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Product Details

Purity:99%

Manufacturer supply top purity 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- 865305-30-2 with ISO standards

Molecular Formula:C14H17IN4O2
Molecular Weight:400.219
Boiling Point:510.2±60.0 °C(Predicted)
PKA:6.89±0.10(Predicted)
PSA：97.74000
Density:1.619±0.06 g/cm3(Predicted)
LogP:3.03010

865305-30-2 Relevant articles

METHODS AND COMPOSITIONS FOR TREATING DISEASES AND CONDITIONS

-

Paragraph 185, (2016/01/25)

Provided herein include methods and comp...

Methods of Using Diaminopyrimidine P2X3 and P2X 2/3 Receptor Modulators for Treatment of Acute and Sub-Acute Cough, Urge to Cough and Chronic Cough, in Respiratory Diseases

-

Paragraph 0155; 0156, (2015/03/04)

Methods for treating cough, chronic coug...

Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X3/P2X2/3 antagonist for the treatment of pain

Carter, David S.,Alam, Muzaffar,Cai, Haiying,Dillon, Michael P.,Ford, Anthony P.D.W.,Gever, Joel R.,Jahangir, Alam,Lin, Clara,Moore, Amy G.,Wagner, Paul J.,Zhai, Yansheng

scheme or table, p. 1628 - 1631 (2009/11/30)

P2X purinoceptors are ligand-gated ion c...

Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases

-

Page/Page column 87-88, (2010/11/26)

Methods for treating respiratory and gas...

865305-30-2 Process route

: 865304-71-8
5-(2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine

: 865305-30-2
[3H]-AF-353

Conditions

Conditions	Yield
With Iodine monochloride; In water; acetic acid; for 17h;	92%
With Iodine monochloride; In acetic acid; at 20 ℃; for 17h;	92%
5-(2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine; With acetic acid; In water; at 20 ℃; for 16h; With Iodine monochloride; In water; at 20 ℃;	92%
With Iodine monochloride; acetic acid; In water; at 20 ℃; for 17h;	92%
With Iodine monochloride; acetic acid; at 24 - 25 ℃; for 42h;
With Iodine monochloride; In water; acetic acid; at 24 - 25 ℃; for 42h; Product distribution / selectivity;

: 2-(5-iodo-2-isopropyl-4-methoxy-phenoxy)-3-phenylamino-acrylonitrile

: 593-85-1,90332-86-8,3425-08-9
diguanidine carbonate

: 865305-30-2
[3H]-AF-353

Conditions

Conditions	Yield
In N,N-dimethyl-formamide; at 120 ℃; for 18h; Product distribution / selectivity;	94%

865305-30-2 Upstream products

865304-71-8
5-(2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine
593-85-1
diguanidine carbonate
1145716-81-9
C₁₄H₁₆INO₃

865305-30-2 Downstream products

865305-31-3
5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-benzonitrile
1050371-24-8
N-[4-amino-5-(5-iodo-2-isopropyl-4-methoxy-phenoxy)-pyrimidin-2-yl]-2-chloro-acetamide
865305-75-5
5-(2,4-diamino-pyrimidin-5-yloxy)-4-isopropyl-2-methoxy-thiobenzamide

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