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15690-57-0

  • Product Name:Enclomiphene
  • Molecular Formula:C26H28 Cl N O
  • Molecular Weight:405.967
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Product Details

pd_meltingpoint:149.0-150.5°

Purity:99%

Factory supply Enclomiphene 15690-57-0 with sufficient production capacity

  • Molecular Formula:C26H28ClNO
  • Molecular Weight:405.967
  • Vapor Pressure:1.77E-10mmHg at 25°C 
  • Melting Point:149.0-150.5° 
  • Boiling Point:509°Cat760mmHg 
  • Flash Point:261.6°C 
  • PSA：12.47000 
  • Density:1.104g/cm3 
  • LogP:6.56260 

TRANS-CLOMIPHENE HCL(Cas 15690-57-0) Usage

InChI:InChI=1/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3/b26-25+

15690-57-0 Relevant articles

TEMPO-Regulated Regio- and Stereoselective Cross-Dihalogenation with Dual Electrophilic X+ Reagents

Kong, Yi,Cao, Tongxiang,Zhu, Shifa

, p. 3004 - 3010 (2021/08/23)

A TEMPO catalyzed cross-dihalogenation r...

Stereoselective Nickel(II)-Catalyzed Addition of Aryl Grignards to Diphenylacetylene in the Synthesis of Zuclomiphene

Blazecka, Peter,Chung, Andrew,Emmett, Michael,Green, Stuart,Karadeolian, Avedis,Le Sueur, Richard,Patel, Dineshkumar,Rey, Allan,Souza, Fabio,Zhao, Yajun

, (2022/03/16)

Stereoselective synthesis of zuclomiphen...

Salts of Zuclomiphene

-

Paragraph 0134-0135, (2021/09/26)

The present invention provides salts of ...

Processes for the Preparation of Zuclomiphene and Intermediates Thereof

-

, (2021/05/21)

The present invention provides processes...

15690-57-0 Process route

1-Bromo-2-phenylacetylene
932-87-6

1-Bromo-2-phenylacetylene

clomiphene
911-45-5,15690-55-8,15690-57-0

clomiphene

Zuclomiphene
911-45-5,15690-55-8,15690-57-0

Zuclomiphene

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1: N-iodo-succinimide; N-chloro-succinimide / 1,2-dichloro-ethane / 24 h / 30 °C / Sealed tube
2: palladium diacetate; tricyclohexylphosphine; potassium hydroxide / tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere
3: potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; methanol / 12 h / 110 °C / Schlenk technique
4: boron tribromide / dichloromethane / 25 h / -78 - -20 °C
5: potassium carbonate / acetone / 1 h / 60 °C
With N-chloro-succinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); palladium diacetate; boron tribromide; potassium carbonate; potassium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; acetone;
Multi-step reaction with 5 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; N-iodo-succinimide; N-chloro-succinimide / 1,2-dichloro-ethane / 24 h / 30 °C / Sealed tube
2: palladium diacetate; tricyclohexylphosphine; potassium hydroxide / tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere
3: potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; methanol / 12 h / 110 °C / Schlenk technique
4: boron tribromide / dichloromethane / 25 h / -78 - -20 °C
5: potassium carbonate / acetone / 1 h / 60 °C
With N-chloro-succinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; boron tribromide; potassium carbonate; potassium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; acetone;
Multi-step reaction with 5 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; N-iodo-succinimide; N-chloro-succinimide / 1,2-dichloro-ethane / 24 h / 30 °C / Sealed tube
2: palladium diacetate; tricyclohexylphosphine; potassium hydroxide / tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere
3: potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; methanol / 12 h / 110 °C / Schlenk technique
4: boron tribromide / dichloromethane / 25 h / -78 - -20 °C
5: potassium carbonate / acetone / 1 h / 60 °C
With N-chloro-succinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; boron tribromide; potassium carbonate; potassium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; acetone;
Multi-step reaction with 5 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; N-iodo-succinimide; N-chloro-succinimide / toluene / 24 h / 30 °C / Sealed tube
2: palladium diacetate; tricyclohexylphosphine; potassium hydroxide / tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere
3: potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; methanol / 12 h / 110 °C / Schlenk technique
4: boron tribromide / dichloromethane / 25 h / -78 - -20 °C
5: potassium carbonate / acetone / 1 h / 60 °C
With N-chloro-succinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; boron tribromide; potassium carbonate; potassium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene;
Multi-step reaction with 5 steps
1: N-iodo-succinimide; N-chloro-succinimide; TEMPOL / 1,2-dichloro-ethane / 24 h / 30 °C / Sealed tube
2: palladium diacetate; tricyclohexylphosphine; potassium hydroxide / tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere
3: potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; methanol / 12 h / 110 °C / Schlenk technique
4: boron tribromide / dichloromethane / 25 h / -78 - -20 °C
5: potassium carbonate / acetone / 1 h / 60 °C
With N-chloro-succinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); TEMPOL; palladium diacetate; boron tribromide; potassium carbonate; potassium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; acetone;
1-Bromo-2-phenylacetylene
932-87-6

1-Bromo-2-phenylacetylene

clomiphene
911-45-5,15690-55-8,15690-57-0

clomiphene

Zuclomiphene
911-45-5,15690-55-8,15690-57-0

Zuclomiphene

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1: N-iodo-succinimide; N-chloro-succinimide / 1,2-dichloro-ethane / 24 h / 30 °C / Sealed tube
2: palladium diacetate; tricyclohexylphosphine; potassium hydroxide / tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere
3: potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; methanol / 12 h / 110 °C / Schlenk technique
4: boron tribromide / dichloromethane / 25 h / -78 - -20 °C
5: potassium carbonate / acetone / 1 h / 60 °C
With N-chloro-succinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); palladium diacetate; boron tribromide; potassium carbonate; potassium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; acetone;
Multi-step reaction with 5 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; N-iodo-succinimide; N-chloro-succinimide / 1,2-dichloro-ethane / 24 h / 30 °C / Sealed tube
2: palladium diacetate; tricyclohexylphosphine; potassium hydroxide / tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere
3: potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; methanol / 12 h / 110 °C / Schlenk technique
4: boron tribromide / dichloromethane / 25 h / -78 - -20 °C
5: potassium carbonate / acetone / 1 h / 60 °C
With N-chloro-succinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; boron tribromide; potassium carbonate; potassium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; acetone;
Multi-step reaction with 5 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; N-iodo-succinimide; N-chloro-succinimide / 1,2-dichloro-ethane / 24 h / 30 °C / Sealed tube
2: palladium diacetate; tricyclohexylphosphine; potassium hydroxide / tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere
3: potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; methanol / 12 h / 110 °C / Schlenk technique
4: boron tribromide / dichloromethane / 25 h / -78 - -20 °C
5: potassium carbonate / acetone / 1 h / 60 °C
With N-chloro-succinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; boron tribromide; potassium carbonate; potassium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; acetone;
Multi-step reaction with 5 steps
1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; N-iodo-succinimide; N-chloro-succinimide / toluene / 24 h / 30 °C / Sealed tube
2: palladium diacetate; tricyclohexylphosphine; potassium hydroxide / tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere
3: potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; methanol / 12 h / 110 °C / Schlenk technique
4: boron tribromide / dichloromethane / 25 h / -78 - -20 °C
5: potassium carbonate / acetone / 1 h / 60 °C
With N-chloro-succinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; boron tribromide; potassium carbonate; potassium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene;
Multi-step reaction with 5 steps
1: N-iodo-succinimide; N-chloro-succinimide; TEMPOL / 1,2-dichloro-ethane / 24 h / 30 °C / Sealed tube
2: palladium diacetate; tricyclohexylphosphine; potassium hydroxide / tetrahydrofuran; water / 2 h / 80 °C / Inert atmosphere
3: potassium hydroxide; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran; methanol / 12 h / 110 °C / Schlenk technique
4: boron tribromide / dichloromethane / 25 h / -78 - -20 °C
5: potassium carbonate / acetone / 1 h / 60 °C
With N-chloro-succinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium(0); TEMPOL; palladium diacetate; boron tribromide; potassium carbonate; potassium hydroxide; tricyclohexylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; 1,2-dichloro-ethane; acetone;

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