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pd_meltingpoint:31 °C
Appearance:Liquid.
Purity:99%
|
Biological Activity |
2,4-dpd is a cell permeable, competitive inhibitor of the oxygen-sensing enzyme hif-α prolyl hydroxylase (hif-ph) [1].hypoxia-inducible factor (hif) is a transcription factor with a key role in cellular responses to hypoxia in a variety of organisms. the hif system plays an important role in angiogenesis, erythropoiesis, energy utilization, glucose/energy metabolism, tumour development, and ischaemic/hypoxic disease. genetic or pharmacological inactivation of the hif hydroxylases results in a constitutive activation of the hif pathway with little or even absent regulation by oxygen remaining. the oxygen-sensing enzyme hif-α prolyl hydroxylase catalyzes hydroxylation of specific prolyl and asparaginyl residues in the regulatory hif-α subunits [2].exposure to 2,4-dpd limited prolyl 4-hydroxylase activity in c. elegans., where their esters are hydrolyzed to form competitors of a -ketoglutarate. 2,4-dpd showed dramatic effects among the progeny. when exposed to a high level of 2,4-dpd (2.7 mm), all progeny died regardless of genotype of c. elegans. the dead embryos arrested at the twofold stage [1]. |
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references |
[1] friedman l, higgin j j, moulder g, et al. prolyl 4-hydroxylase is required for viability and morphogenesis in caenorhabditis elegans[j]. proceedings of the national academy of sciences, 2000, 97(9): 4736-4741.[2] schofield c j, ratcliffe p j. signalling hypoxia by hif hydroxylases[j]. biochemical and biophysical research communications, 2005, 338(1): 617-626. |
InChI:InChI=1/C11H13NO4/c1-3-15-10(13)8-5-6-12-9(7-8)11(14)16-4-2/h5-7H,3-4H2,1-2H3
The heterofunctional lactone furo[3,4-b]...
Herein we report a selective DIBAL-H-med...
Provided herein are compounds of Formula...
The chemical inertness of abundant and c...
pyridine-2,4-dicarboxylic acid
ethanol
diethyl pyridine-2,4-dicarboxylate
| Conditions | Yield |
|---|---|
|
With
toluene-4-sulfonic acid;
for 24h;
Heating;
|
100% |
|
With
toluene-4-sulfonic acid;
In
toluene;
at 110 ℃;
|
88% |
|
ethanol;
With
thionyl chloride;
at 0 ℃;
for 0.5h;
Inert atmosphere;
pyridine-2,4-dicarboxylic acid;
In
ethanol;
for 3h;
Inert atmosphere;
Reflux;
|
82% |
|
With
toluene-4-sulfonic acid;
for 24h;
Reflux;
|
81% |
|
With
toluene-4-sulfonic acid;
at 80 ℃;
for 16h;
|
79% |
|
With
sulfuric acid;
|
|
|
With
sulfuric acid;
Heating;
|
|
|
With
sulfuric acid;
|
|
|
With
sulfuric acid;
Reflux;
|
|
|
With
sulfuric acid;
In
water;
at 78 ℃;
for 15h;
|
24.49 g |
|
With
toluene-4-sulfonic acid;
Reflux;
|
|
|
With
thionyl chloride;
Reflux;
|
pyridine-2,4-dicarboxylic acid
diethyl pyridine-2,4-dicarboxylate
| Conditions | Yield |
|---|---|
|
With
sulfuric acid;
In
ethanol;
at 70 ℃;
for 14h;
|
6 g |
pyridine-2,4-dicarboxylic acid
ethanol
pyridine
2-oxo-propionic acid ethyl ester
KDM5-C70
pyridine-2,4-dicarbaldehyde
ethyl 2-(hydroxymethyl)pyridine-4-carboxylate
4-(hydroxymethyl)pyridine-2-carbaldehyde
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