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pd_meltingpoint:31 °C
Appearance:Liquid.
Purity:99%
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Biological Activity |
2,4-dpd is a cell permeable, competitive inhibitor of the oxygen-sensing enzyme hif-α prolyl hydroxylase (hif-ph) [1].hypoxia-inducible factor (hif) is a transcription factor with a key role in cellular responses to hypoxia in a variety of organisms. the hif system plays an important role in angiogenesis, erythropoiesis, energy utilization, glucose/energy metabolism, tumour development, and ischaemic/hypoxic disease. genetic or pharmacological inactivation of the hif hydroxylases results in a constitutive activation of the hif pathway with little or even absent regulation by oxygen remaining. the oxygen-sensing enzyme hif-α prolyl hydroxylase catalyzes hydroxylation of specific prolyl and asparaginyl residues in the regulatory hif-α subunits [2].exposure to 2,4-dpd limited prolyl 4-hydroxylase activity in c. elegans., where their esters are hydrolyzed to form competitors of a -ketoglutarate. 2,4-dpd showed dramatic effects among the progeny. when exposed to a high level of 2,4-dpd (2.7 mm), all progeny died regardless of genotype of c. elegans. the dead embryos arrested at the twofold stage [1]. |
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references |
[1] friedman l, higgin j j, moulder g, et al. prolyl 4-hydroxylase is required for viability and morphogenesis in caenorhabditis elegans[j]. proceedings of the national academy of sciences, 2000, 97(9): 4736-4741.[2] schofield c j, ratcliffe p j. signalling hypoxia by hif hydroxylases[j]. biochemical and biophysical research communications, 2005, 338(1): 617-626. |
InChI:InChI=1/C11H13NO4/c1-3-15-10(13)8-5-6-12-9(7-8)11(14)16-4-2/h5-7H,3-4H2,1-2H3
The heterofunctional lactone furo[3,4-b]...
Herein we report a selective DIBAL-H-med...
Provided herein are compounds of Formula...
The chemical inertness of abundant and c...
pyridine-2,4-dicarboxylic acid
ethanol
diethyl pyridine-2,4-dicarboxylate
| Conditions | Yield |
|---|---|
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With toluene-4-sulfonic acid; for 24h; Heating;
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100% |
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With toluene-4-sulfonic acid; In toluene; at 110 ℃;
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88% |
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ethanol; With thionyl chloride; at 0 ℃; for 0.5h; Inert atmosphere;
pyridine-2,4-dicarboxylic acid; In ethanol; for 3h; Inert atmosphere; Reflux;
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82% |
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With toluene-4-sulfonic acid; for 24h; Reflux;
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81% |
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With toluene-4-sulfonic acid; at 80 ℃; for 16h;
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79% |
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With sulfuric acid;
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With sulfuric acid; Heating;
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With sulfuric acid;
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With sulfuric acid; Reflux;
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With sulfuric acid; In water; at 78 ℃; for 15h;
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24.49 g |
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With toluene-4-sulfonic acid; Reflux;
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With thionyl chloride; Reflux;
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pyridine-2,4-dicarboxylic acid
diethyl pyridine-2,4-dicarboxylate
| Conditions | Yield |
|---|---|
|
With sulfuric acid; In ethanol; at 70 ℃; for 14h;
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6 g |
pyridine-2,4-dicarboxylic acid
ethanol
pyridine
2-oxo-propionic acid ethyl ester
KDM5-C70
pyridine-2,4-dicarbaldehyde
ethyl 2-(hydroxymethyl)pyridine-4-carboxylate
4-(hydroxymethyl)pyridine-2-carbaldehyde
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