What is the Hydroxypioglitazone?

Hydroxypioglitazone is Off-White Solid, while it's Molecular Formula is C19H20N2O4S. Off-White Solid A metabolite of Pioglitazone (P471000).

What is the CAS number for Hydroxypioglitazone?

The CAS number of Hydroxypioglitazone is 146062-44-4.

What is Hydroxypioglitazone (146062-44-4) used for?

Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC50 = 2.1 μM).InChI:InChI=1/C19H20N2O4S/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17/h2-7,11-12,17,22H,8-10H2,1H3,(H,21,23,24)

What is the Hydroxypioglitazone?

Hydroxypioglitazone is Off-White Solid, while it's Molecular Formula is C19H20N2O4S. Off-White Solid A metabolite of Pioglitazone (P471000).

What is the CAS number for Hydroxypioglitazone?

The CAS number of Hydroxypioglitazone is 146062-44-4.

What is Hydroxypioglitazone (146062-44-4) used for?

Hydroxy pioglitazone is a major metabolite of the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Item Nos. 71745 | 22263 | 10028). It is formed from pioglitazone by the cytochrome P450 (CYP) isoform CYP2C8 with minor contributions from CYP3A4. Hydroxy pioglitazone binds to PPARγ (Ki = 1.2 μM) and activates PPARγ in a time-resolved FRET (TR-FRET) assay (EC50 = 2.1 μM).InChI:InChI=1/C19H20N2O4S/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17/h2-7,11-12,17,22H,8-10H2,1H3,(H,21,23,24)

Product classification

Contact us

Tel：+86-0533-2185556
Fax：+86-0533-2185556
Phone：+86 15965530500
Website：http://www.shandonghangyu.com/
Email：admin@hangyubiotech.com
Address：Room 2516, Dingcheng Building, Beijing Road, Zhangdian District, Zibo City, Shandong Province

146062-44-4

Product Name:Hydroxypioglitazone
Molecular Formula:C₁₉H₂₀N₂O₄S
Molecular Weight:372.445
Appearance:Off-White Solid

Inquiry

Product Details

pd_meltingpoint:157-158 °C

Appearance:Off-White Solid

Purity:99%

Chinese factory supply Hydroxypioglitazone 146062-44-4 in stock with high standard

Molecular Formula:C19H20N2O4S
Molecular Weight:372.445
Appearance/Colour:Off-White Solid
Vapor Pressure:1.28E-16mmHg at 25°C
Melting Point:157-158 °C
Refractive Index:1.628
Boiling Point:627.6 °C at 760 mmHg
Flash Point:333.4 °C
PSA：113.82000
Density:1.325 g/cm³
LogP:2.97930

Hydroxypioglitazone(Cas 146062-44-4) Usage

InChI:InChI=1/C19H20N2O4S/c1-12(22)14-4-5-15(20-11-14)8-9-25-16-6-2-13(3-7-16)10-17-18(23)21-19(24)26-17/h2-7,11-12,17,22H,8-10H2,1H3,(H,21,23,24)

146062-44-4 Relevant articles

PROCESS FOR PREPARING 5-[[4-[2-[5-(1-HYDROXYETHYL)-2-PYRIDINYL]ETHOXY]PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE AND SALTS THEREOF

-

Paragraph 0261; 0271; 0272, (2018/07/29)

The disclosure provides a process of mak...

2,4-THIAZOLIDINEDIONE DERIVATIVES IN THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS

-

Page/Page column 23; 26, (2015/11/17)

The present invention provides 5-(4-(2-(...

Synthesis and biological activity of metabolites of the antidiabetic, antihyperglycemic agent pioglitazone

Tanis, Steven P.,Parker, Timothy T.,Colca, Jerry R.,Fisher, Roberta M.,Kletzein, Rolf F.

, p. 5053 - 5063 (2007/10/03)

Pioglitazone (5-(4-(2-(5-ethyl-2-pyridyl...

Studies on antidiabetic agents. XII. Synthesis and activity of the metabolites of (±)-5-[p-[2-(5-ethyl-2-pyridyl)ethoxy]benzyl]-2,4- thiazolidinedione (pioglitazone)

Sohda,Ikeda,Meguro

, p. 2168 - 2172 (2007/10/03)

The metabolites of (±)-5-[p-[2-(5-ethyl-...

146062-44-4 Process route

: 184766-39-0
5-(4-(2-(5-(1-(methoxymethoxy)ethyl)pyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione

: 146062-44-4
Hydroxypioglitazone

Conditions

Conditions	Yield
With hydrogenchloride; In methanol; for 2h; Heating;	98%
With hydrogenchloride; In methanol; water; for 4h; Reflux;	250 mg
With hydrogenchloride; In ethanol; water; for 4h; Reflux;	250 mg

: 146062-60-4
methyl 2-bromo-3-<4-<2-<5-(1-memthoxymethoxyethyl)-2-pyridyl>ethoxy>phenyl>propionate

: 146062-44-4
Hydroxypioglitazone

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: NaOAc / ethanol / 4 h / Heating 2: 2N HCl / 20 h / Heating With hydrogenchloride; sodium acetate; In ethanol;
With hydrogenchloride; sodium acetate; thiourea; In ethanol;

146062-44-4 Upstream products

1026292-59-0
2-Imino-5-(4-{2-[5-(1-methoxymethoxy-ethyl)-pyridin-2-yl]-ethoxy}-benzyl)-thiazolidin-4-one
184766-39-0
5-(4-(2-(5-(1-(methoxymethoxy)ethyl)pyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione
36357-38-7
1-(6-methyl-pyridin-3-yl)-ethanone
56019-64-8
5-(1-hydroxyethyl)-2-methylpyridine

146062-44-4 Downstream products

146062-45-5
Ketopioglitazone

Relevant Products

Prasugrel
CAS：115473-15-9
OXACILLIN SODIUM
CAS：1173-88-2
BMS-986205
CAS：1923833-60-6
Taltirelin
CAS：103300-74-9