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1204669-58-8

  • Product Name:Epacadostat (INCB024360)
  • Molecular Formula:C11H13BrFN7O4S
  • Molecular Weight:438.237
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Product Details

Purity:99%

China cas 1204669-58-8 factory wholesale Epacadostat (INCB024360) at affordable price

  • Molecular Formula:C11H13BrFN7O4S
  • Molecular Weight:438.237
  • Boiling Point:700.9±70.0 °C(Predicted) 
  • PKA:7.65±0.69(Predicted) 
  • PSA：176.14000 
  • Density:2.01±0.1 g/cm3(Predicted) 
  • LogP:2.74210 

1204669-58-8 Relevant articles

PROTAC compound for targeted degradation of IDO1, and preparation method and application thereof

-

Paragraph 0024-0026; 0054, (2020/06/17)

The invention provides a PROTAC compound...

Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation

Stanley, Christopher P.,Maghzal, Ghassan J.,Ayer, Anita,Talib, Jihan,Giltrap, Andrew M.,Shengule, Sudhir,Wolhuter, Kathryn,Wang, Yutang,Chadha, Preet,Suarna, Cacang,Prysyazhna, Oleksandra,Scotcher, Jenna,Dunn, Louise L.,Prado, Fernanda M.,Nguyen, Nghi,Odiba, Jephthah O.,Baell, Jonathan B.,Stasch, Johannes-Peter,Yamamoto, Yorihiro,Di Mascio, Paolo,Eaton, Philip,Payne, Richard J.,Stocker, Roland

, p. 548 - 552 (2019/03/06)

Singlet molecular oxygen (1O2) has well-...

Preparation method of IDO1 inhibitor Epacadostat intermediate

-

Paragraph 0008; 0015; 0033; 0067; 0068, (2018/06/26)

The invention relates to the drug synthe...

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology

Yue, Eddy W.,Sparks, Richard,Polam, Padmaja,Modi, Dilip,Douty, Brent,Wayland, Brian,Glass, Brian,Takvorian, Amy,Glenn, Joseph,Zhu, Wenyu,Bower, Michael,Liu, Xiangdong,Leffet, Lynn,Wang, Qian,Bowman, Kevin J.,Hansbury, Michael J.,Wei, Min,Li, Yanlong,Wynn, Richard,Burn, Timothy C.,Koblish, Holly K.,Fridman, Jordan S.,Emm, Tom,Scherle, Peggy A.,Metcalf, Brian,Combs, Andrew P.

supporting information, p. 486 - 491 (2017/05/19)

A data-centric medicinal chemistry appro...

1204669-58-8 Process route

N-[2-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]sulfamide
1204669-70-4

N-[2-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]sulfamide

4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N’-hydroxy-1,2,5-oxadiazole-3-carboximidamide
1204669-37-3,1204669-58-8

4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N’-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Conditions
Conditions Yield
With sodium hydroxide; In tetrahydrofuran; water; at 2 - 20 ℃; for 16h; Solvent;
95.4%
With sodium hydroxide; In tetrahydrofuran; at -10 - 20 ℃; for 3h; Temperature;
88.5%
With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;
80%
With sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Large scale;
78%
With sodium hydroxide; In methanol; water; at 25 ℃; for 3h;
75%
With sodium hydroxide; In tetrahydrofuran; at 0 - 40 ℃; for 5h;
65.6%
With trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Solvent; Temperature; Large scale;
3290 g
With water; sodium hydroxide; In methanol;
N-[2-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]sulfamide
1204669-70-4

N-[2-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl]sulfamide

(Z)-4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
1204669-37-3,1204669-58-8

(Z)-4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide

Conditions
Conditions Yield
With trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; water; at 0 - 16 ℃; for 5h; Temperature; Time; Large scale;
81.7%
With sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere; Large scale;
78%

1204669-58-8 Upstream products

  • 1204669-69-1
    1204669-69-1

    (Ν-(2-((4-(4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl)amino)ethyl)tert-butylsulfamoyl)carbamate

  • 1204669-63-5
    1204669-63-5

    4-(3-bromo-4-fluorophenyl)-3-{4-[(2-methoxyethyl)amino]-1,2,5-oxadiazol-3-yl}-1,2,4-oxadiazol-5(4H)-one

  • 1204669-64-6
    1204669-64-6

    4-(3-bromo-4-fluorophenyl)-3-{4-[(2-hydroxyethyl)amino]-1,2,5-oxadiazol-3-yl}-1,2,4-oxadiazol-5(4H)-one

  • 1204669-65-7
    1204669-65-7

    2-({4-[4-(3-bromo-4-fluorophenyl)-5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl]-1,2,5-oxadiazol-3-yl}amino)ethyl methanesulfonate

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