212141-54-3

  • Product Name:Vatalanib base
  • Molecular Formula:C20H15ClN4
  • Molecular Weight:346.819
Inquiry

Product Details

pd_meltingpoint:209-212oC

Purity:99%

Export Top Purity Vatalanib base 212141-54-3 In Stock

  • Molecular Formula:C20H15ClN4
  • Molecular Weight:346.819
  • Vapor Pressure:8.48E-14mmHg at 25°C 
  • Melting Point:209-212oC 
  • Refractive Index:1.711 
  • Boiling Point:587.8 °C at 760 mmHg 
  • PKA:5.46±0.10(Predicted) 
  • Flash Point:309.3 °C 
  • PSA:50.70000 
  • Density:1.33 g/cm3 
  • LogP:5.08560 

Vatalanib base(Cas 212141-54-3) Usage

Definition

ChEBI: A member of the class of phthalazines that is phthalazine in which the hydrogens at positions 1 and 4have been replaced by a p-chlorophenylamino group and a pyridin-4-ylmethyl group, respectively. It is a multi-targeted tyrosine kinase inhibit r for all isoforms of VEGFR, PDGFR and c-Kit.

InChI:InChI=1/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)

212141-54-3 Relevant articles

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212141-54-3 Process route

bromochlorobenzene
106-39-8

bromochlorobenzene

1-amino-4-(pyridin-4-yl)methylpyridazine

1-amino-4-(pyridin-4-yl)methylpyridazine

vatalanib
212141-54-3

vatalanib

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl-formamide; at 110 - 115 ℃; for 5h; Temperature;
92.8%
1-Chloro-4-iodobenzene
637-87-6

1-Chloro-4-iodobenzene

1-amino-4-(pyridin-4-yl)methylpyridazine

1-amino-4-(pyridin-4-yl)methylpyridazine

vatalanib
212141-54-3

vatalanib

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl-formamide; at 100 - 105 ℃; for 5h;
93.4%

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