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pd_meltingpoint:162-164°C
Appearance:White crystalline solid
Purity:99%
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Biochem/physiol Actions |
Valganciclovir hydrochloride hydrate is an antiviral used to treat cytomegalovirus infection. It is the prodrug of ganciclovir, a synthetic analog of 2′-deoxy-guanosine which is phosphorylated to a dGTP analog that competitively inhibits the incorporation of dGTP by viral DNA polymerase. |
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Brand name |
Valcyte (Roche). |
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General Description |
Valganciclovir Hydrochloride is the L-valyl ester of ganciclovir and an antiviral drug, widely used to treat cytomegalovirus infections.Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. |
InChI:InChI=1/C14H22N6O5.ClH/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22;/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22);1H/t8?,9-;/m0./s1
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2-(2-amino-1,6 dihydro-6-oxo-purine-9-yl)-methoxy-3-hydroxy-1-propyl-N-(benzyloxy carbonyl)-L-valinate
2-(2-amino-1,6-dihydro-6-oxo-purine-9-yl)-methoxy-3-hydroxy-1-propyl-L-valinate hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; hydrogen;
palladium 10% on activated carbon;
In
ethanol; water;
for 12 - 20h;
|
2-(2-amino-1,6 dihydro-6-oxo-purine-9-yl)-methoxy-3-hydroxy-1-propyl-N-(benzyloxy carbonyl)-L-valinate
valganciclovir hydrochloride
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; palladium on activated charcoal; hydrogen;
In
methanol; water;
at 20 ℃;
for 18h;
under 1500.15 Torr;
|
82% |
|
With
hydrogenchloride; hydrogen;
palladium on carbon;
In
water; isopropyl alcohol;
at 25 - 40 ℃;
for 1h;
under 367.786 - 735.572 Torr;
Product distribution / selectivity;
|
77.5% |
|
With
hydrogenchloride; hydrogen;
palladium 10% on activated carbon;
In
ethanol; water;
at 20 - 40 ℃;
Product distribution / selectivity;
|
|
|
With
hydrogenchloride; hydrogen;
palladium 10% on activated carbon;
In
ethanol; water;
at 25 - 30 ℃;
for 12 - 20h;
|
|
|
2-(2-amino-1,6 dihydro-6-oxo-purine-9-yl)-methoxy-3-hydroxy-1-propyl-N-(benzyloxy carbonyl)-L-valinate;
With
hydrogenchloride; hydrogen;
palladium 10% on activated carbon;
In
methanol; water;
at 25 - 30 ℃;
under 514.901 - 735.572 Torr;
With
pyrographite; triphenylphosphine;
In
methanol; water;
at 25 - 30 ℃;
Product distribution / selectivity;
|
|
|
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen;
In
ethanol; water;
at 20 ℃;
for 15h;
under 2250.23 Torr;
|
16.8 g |
2-(2-amino-1,6 dihydro-6-oxo-purine-9-yl)-methoxy-3-hydroxy-1-propyl-N-(benzyloxy carbonyl)-L-valinate
L-valine
O-mesyl ganciclovir
2-[(2-amino-1,6-dihydro-6-oxopurin-9-yl)methyloxy]-3-hydroxypropyl 2'-(S)-azido-3'-methylbutanoate
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