JZL 184 is , while it's Molecular Formula is C27H24N2O9. JZL184 is a strong and selective inhibitor of Monoglyceride Lipase.

What is the CAS number for JZL 184?

The CAS number of JZL 184 is 1101854-58-3.

What is JZL 184 (1101854-58-3) used for?

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 μM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively. When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.

JZL 184 is , while it's Molecular Formula is C27H24N2O9. JZL184 is a strong and selective inhibitor of Monoglyceride Lipase.

What is the CAS number for JZL 184?

The CAS number of JZL 184 is 1101854-58-3.

What is JZL 184 (1101854-58-3) used for?

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 μM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively. When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.

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small-molecule inhibitor
intermediate
Pharmaceutical intermediate
Biochemical reagent
fire retardant
chemical reagent
ionic liquid
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1101854-58-3

Product Name:JZL 184
Molecular Formula:C₂₇H₂₄N₂O₉
Molecular Weight:520.496

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Product Details

Purity:99%

Factory supply JZL 184 1101854-58-3 with sufficient production capacity

Molecular Formula:C27H24N2O9
Molecular Weight:520.496
Boiling Point:706.4 °C at 760 mmHg
PKA:13.32±0.29(Predicted)
Flash Point:381 °C
PSA：132.51000
Density:1.467 g/cm³
LogP:4.66020

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