GRT6005 is , while it's Molecular Formula is C24H27FN2O. Cebranopadol can be obtained from 1,4-Cyclohexanedione Monoethylene Acetal (C987955) which is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione Monoethylene Acetal (C987955) is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

What is the CAS number for GRT6005?

The CAS number of GRT6005 is 863513-91-1.

What is GRT6005 (863513-91-1) used for?

GRT6005 is a high-quality, pure glycerol product derived from renewable resources. It is a colorless, odorless, and viscous liquid with a sweet taste. Glycerol is a versatile and essential chemical compound with a wide range of applications across various industries due to its unique properties, such as its hygroscopic nature, solubility in water, and ability to act as a humectant, solvent, and emulsifier.

GRT6005 is , while it's Molecular Formula is C24H27FN2O. Cebranopadol can be obtained from 1,4-Cyclohexanedione Monoethylene Acetal (C987955) which is used in the preparation of series of potent analgesic compounds. 1,4-Cyclohexanedione Monoethylene Acetal (C987955) is also used as a building block in the synthesis of tritium labelled probes for the autoradiography study of the dopamine reuptake complex.

What is the CAS number for GRT6005?

The CAS number of GRT6005 is 863513-91-1.

What is GRT6005 (863513-91-1) used for?

GRT6005 is a high-quality, pure glycerol product derived from renewable resources. It is a colorless, odorless, and viscous liquid with a sweet taste. Glycerol is a versatile and essential chemical compound with a wide range of applications across various industries due to its unique properties, such as its hygroscopic nature, solubility in water, and ability to act as a humectant, solvent, and emulsifier.

Product classification

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863513-91-1

Product Name:GRT6005
Molecular Formula:C24H27FN2O
Molecular Weight:378.49

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Product Details

Purity:99%

Factory supply GRT6005 863513-91-1 with sufficient stock and high standard

Molecular Formula:C24H27FN2O
Molecular Weight:378.49
Boiling Point:547.5±50.0 °C(Predicted)
PKA:16.79±0.40(Predicted)
PSA：28.26000
Density:1.23±0.1 g/cm3(Predicted)
LogP:5.10610

863513-91-1 Relevant articles

Improved and Flexible Synthetic Access to the Spiroindole Backbone of Cebranopadol

Christoffers, Jens,Schmidtmann, Marc,Wachtendorf, Daniel

supporting information, p. 6420 - 6423 (2020/09/02)

By changing the dimethylamino to a nitro...

Discovery of a potent analgesic NOP and opioid receptor agonist: Cebranopadol

Schunk, Stefan,Linz, Klaus,Hinze, Claudia,Frormann, Sven,Oberb?rsch, Stefan,Sundermann, Bernd,Zemolka, Saskia,Englberger, Werner,Germann, Tieno,Christoph, Thomas,K?gel, Babette-Y.,Schr?der, Wolfgang,Harlfinger, Stephanie,Saunders, Derek,Kless, Achim,Schick, Hans,Sonnenschein, Helmut

supporting information, p. 857 - 862 (2014/09/29)

In a previous communication, our efforts...

CRYSTALLINE (1R,4R)-6'-FLUORO-N,N-DIMETHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO[3,4,B]INDOL]-4-AMINE

-

Paragraph 0410, (2013/03/26)

Crystalline forms of (1r,4r)-6′-fluoro-N...

CRYSTALLINE (1R,4R)-6'-FLUORO-N,N-DIMETHYL-4-PHENYL-4',9'-DIHYDRO-3'H-SPIRO[CYCLOHEXANE-1,1'-PYRANO[3,4,B]INDOL]-4-AMINE

-

Page/Page column 82; 83, (2013/03/26)

The present invention relates to crystal...

863513-91-1 Process route

: 65619-20-7
4-dimethylamino-4-phenylcyclohexanone

: 101349-12-6
2-(5-fluoro-1H-indol-3-yl)ethanol

: 863513-91-1
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine

Conditions

Conditions	Yield
With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 22 - 40 ℃; for 65h; Inert atmosphere;	91%
4-dimethylamino-4-phenylcyclohexanone; 2-(5-fluoro-1H-indol-3-yl)ethanol; With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 - 45 ℃; for 65h; Inert atmosphere; With sodium hydroxide; In dichloromethane; water; at 21 - 22 ℃;	91%
With sulfuric acid; In acetic acid; at 45 - 60 ℃;	60%
With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 - 20 ℃;	3.5 g
With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 - 20 ℃; Reagent/catalyst; Solvent; Temperature; Time;	3.5 g
4-dimethylamino-4-phenylcyclohexanone; 2-(5-fluoro-1H-indol-3-yl)ethanol; With sulfuric acid; acetic acid; at 45 - 60 ℃; With diethylamine; In isopropyl alcohol; at 20 ℃; Reagent/catalyst; Temperature; Solvent; Concentration;
With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 - 20 ℃;
With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 20 ℃; for 20h; Inert atmosphere;	955 mg

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: C₂₂H₂₃FN₂O

: 863513-91-1
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine

Conditions

Conditions	Yield
With formic acid; In water; at 70 ℃; for 16h;	280 mg

863513-91-1 Upstream products

65619-20-7
4-dimethylamino-4-phenylcyclohexanone
101349-12-6
2-(5-fluoro-1H-indol-3-yl)ethanol
4746-97-8
cyclohexanedione monoethylene ketal
65619-92-3
8-(dimethylamino)-1,4-dioxaspiro-[4.5]-decane-8-carbonitrile

863513-91-1 Downstream products

863513-92-2
trans-6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenyl-spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine hemicitrate
1443050-72-3
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine sulfate
1443039-98-2
(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indole]-4-amine hydrochloride

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