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Purity:99%
The invention relates to a preparation m...
The present invention relates to imidazo...
The invention relates to imidazopyrazine...
The invention belongs to the technical f...
2-chloro-3-cyanopyrazine
C-(3-chloropyrazin-2-yl)-methylamine hydrochloride salt
Conditions | Yield |
---|---|
With hydrogen; acetic acid; at 20 ℃; for 36h;
|
100% |
2-chloro-3-cyanopyrazine; With hydrogen; acetic acid; at 20 ℃; for 48h; under 7500.75 Torr; Autoclave;
With hydrogenchloride; In methanol; water;
|
35% |
2-chloro-3-cyanopyrazine; With hydrogen; acetic acid; In water; at 20 ℃; under 3000.3 Torr;
With hydrogenchloride; In diethyl ether; ethyl acetate; at 20 ℃; Cooling with ice;
|
153.5 g |
2-chloro-3-cyanopyrazine; With hydrogen; acetic acid; In water; at 20 ℃; under 3000.3 Torr;
With hydrogenchloride; In diethyl ether; ethyl acetate; at 20 ℃; for 0.5h; Cooling with ice;
|
|
2-chloro-3-cyanopyrazine; With hydrogen; acetic acid; In water; acetonitrile; at 20 ℃; for 4h;
With hydrogenchloride; In diethyl ether; ethyl acetate; at 20 ℃; Cooling with ice;
|
|
2-chloro-3-cyanopyrazine; With hydrogenchloride; hydrogen; acetic acid; In water; at 20 ℃; under 3000.3 Torr;
With hydrogenchloride; In diethyl ether; ethyl acetate; at 20 ℃; Cooling with ice;
|
|
With hydrogen; acetic acid; In water; at 20 ℃; for 15h; under 3000.3 Torr;
|
|
2-chloro-3-cyanopyrazine; With hydrogen; acetic acid; at 20 ℃; under 3375.34 Torr;
With hydrogenchloride; In ethyl acetate; at 50 ℃;
|
23 g |
2-chloro-3-cyanopyrazine; With indium(III) chloride; sodium tetrahydroborate; In tetrahydrofuran; at 30 - 40 ℃;
With hydrogenchloride; In ethyl acetate; at 5 ℃; Reagent/catalyst;
|
44.3 g |
2-((3-chloropyrazin-2-yl)methyl)isoindoline-1,3-dione
C-(3-chloropyrazin-2-yl)-methylamine hydrochloride salt
Conditions | Yield |
---|---|
2-((3-chloropyrazin-2-yl)methyl)isoindoline-1,3-dione; With hydrazine; In methanol; at 60 ℃; for 1h;
With hydrogenchloride; In toluene; Product distribution / selectivity;
|
2-((3-chloropyrazin-2-yl)methyl)isoindoline-1,3-dione
1-(3-chloro-pyrazin-2-ylmethyl)-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1*3,7*]decane; chloride
N-(3-chloro-pyrazin-2-ylmethyl)-N-formyl-formamide
2-chloro-3-cyanopyrazine
N-[(2-chlorophenyl(methyl))]-3-oxocyclobutanecarboxamide
benzyl 4-(((3-chloropyrazin-2-yl)methyl)carbamoyl)-2-cyanopiperidine-1-carboxylate
benzyl (S)-2-(((3-chloropyrazin-2-yl)methyl)carbamoyl)pyrrolidine-1-carboxylate
benzyl (2S)-2-([(3-chloropyrazin-2-yl)methyl]carbamoyl)piperidine-1-carboxylate
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