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Purity:99%
The invention relates to a preparation m...
The present invention relates to imidazo...
The invention relates to imidazopyrazine...
The invention belongs to the technical f...
2-chloro-3-cyanopyrazine
C-(3-chloropyrazin-2-yl)-methylamine hydrochloride salt
| Conditions | Yield |
|---|---|
|
With
hydrogen; acetic acid;
at 20 ℃;
for 36h;
|
100% |
|
2-chloro-3-cyanopyrazine;
With
hydrogen; acetic acid;
at 20 ℃;
for 48h;
under 7500.75 Torr;
Autoclave;
With
hydrogenchloride;
In
methanol; water;
|
35% |
|
2-chloro-3-cyanopyrazine;
With
hydrogen; acetic acid;
In
water;
at 20 ℃;
under 3000.3 Torr;
With
hydrogenchloride;
In
diethyl ether; ethyl acetate;
at 20 ℃;
Cooling with ice;
|
153.5 g |
|
2-chloro-3-cyanopyrazine;
With
hydrogen; acetic acid;
In
water;
at 20 ℃;
under 3000.3 Torr;
With
hydrogenchloride;
In
diethyl ether; ethyl acetate;
at 20 ℃;
for 0.5h;
Cooling with ice;
|
|
|
2-chloro-3-cyanopyrazine;
With
hydrogen; acetic acid;
In
water; acetonitrile;
at 20 ℃;
for 4h;
With
hydrogenchloride;
In
diethyl ether; ethyl acetate;
at 20 ℃;
Cooling with ice;
|
|
|
2-chloro-3-cyanopyrazine;
With
hydrogenchloride; hydrogen; acetic acid;
In
water;
at 20 ℃;
under 3000.3 Torr;
With
hydrogenchloride;
In
diethyl ether; ethyl acetate;
at 20 ℃;
Cooling with ice;
|
|
|
With
hydrogen; acetic acid;
In
water;
at 20 ℃;
for 15h;
under 3000.3 Torr;
|
|
|
2-chloro-3-cyanopyrazine;
With
hydrogen; acetic acid;
at 20 ℃;
under 3375.34 Torr;
With
hydrogenchloride;
In
ethyl acetate;
at 50 ℃;
|
23 g |
|
2-chloro-3-cyanopyrazine;
With
indium(III) chloride; sodium tetrahydroborate;
In
tetrahydrofuran;
at 30 - 40 ℃;
With
hydrogenchloride;
In
ethyl acetate;
at 5 ℃;
Reagent/catalyst;
|
44.3 g |
2-((3-chloropyrazin-2-yl)methyl)isoindoline-1,3-dione
C-(3-chloropyrazin-2-yl)-methylamine hydrochloride salt
| Conditions | Yield |
|---|---|
|
2-((3-chloropyrazin-2-yl)methyl)isoindoline-1,3-dione;
With
hydrazine;
In
methanol;
at 60 ℃;
for 1h;
With
hydrogenchloride;
In
toluene;
Product distribution / selectivity;
|
2-((3-chloropyrazin-2-yl)methyl)isoindoline-1,3-dione
1-(3-chloro-pyrazin-2-ylmethyl)-3,5,7-triaza-1-azonia-tricyclo[3.3.1.1*3,7*]decane; chloride
N-(3-chloro-pyrazin-2-ylmethyl)-N-formyl-formamide
2-chloro-3-cyanopyrazine
N-[(2-chlorophenyl(methyl))]-3-oxocyclobutanecarboxamide
benzyl 4-(((3-chloropyrazin-2-yl)methyl)carbamoyl)-2-cyanopiperidine-1-carboxylate
benzyl (S)-2-(((3-chloropyrazin-2-yl)methyl)carbamoyl)pyrrolidine-1-carboxylate
benzyl (2S)-2-([(3-chloropyrazin-2-yl)methyl]carbamoyl)piperidine-1-carboxylate
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