357336-20-0

  • Product Name:Brivaracetam
  • Molecular Formula:C11H20 N2 O2
  • Molecular Weight:212.292
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Product Details

pd_meltingpoint:76.38°

Purity:99%

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What is the brivaracetam ?

brivaracetam is , while it's Molecular Formula is C11H20 N2 O2. Brivaracetam, is a 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.

What is the CAS number for brivaracetam ?

The CAS number of brivaracetam is 357336-20-0.

More information of brivaracetam 357336-20-0 are:

Synonyms

Brivaracetam;UCB 34714

CAS Number

357336-20-0

Molecular Formula

C11H20 N2 O2

Molecular Weight

212.292

Density

1.062

Melting Point

76.38°

Boiling Point

409.3±28.0 °C(Predicted)

HS CODE

2933990090

PSA

63.40000

LogP

1.53710

Pka

15.74±0.50(Predicted)

What is brivaracetam (357336-20-0) used for?

Brivaracetam, a novel oral antiepileptic drug with a high affinity for synaptic vesicle protein 2A (SV2A), was approved in Europe and the US as an adjunctive therapy for the treatment of partial onset seizures with or without secondary generalization in patients aged 16 or older.42 Brivaracetam is very closely related to levetiracetam, an antiepileptic treatment whose immediate release formulation has been available in the United States as a generic drug since 2008, but whose extended release formulation is under patent protection until 2028. The two drugs, which were both developed by UCB Pharma, are structurally similar with brivaracetam having an n-propyl group at the C-4 position of the pyrrolidinone ring and levetiracetam having a hydrogen at this same position. A systematic investigation of the various substitutions of levetiracetam resulted in the identification of more potent and selective SV2A ligands and ultimately culminated in the discovery of brivaracetam, which has greater affinity for SV2A, improved selectivity, more rapid brain penetration, and faster onset of action against seizures than levetiracetam.

Articles related to brivaracetam:

Article

Source

Chiral resolution method of brivaracetam

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Paragraph 0038-0042; 0049-0051; 0058-0060, (2022/01/12)

Novel preparation method of iracetam

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Paragraph 0021-0027, (2021/10/13)

How to get the best price on brivaracetam?

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