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763113-22-0

  • Product Name:Olaparib
  • Molecular Formula:C24H23FN4O3
  • Molecular Weight:434.47
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Product Details

Purity:99%

Quality products make an important contribution to long-term revenue and profitability. Factory Supply industrial standard Olaparib 763113-22-0 In Stock

1.What is the Olaparib ?

Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 μM). It can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.[Cayman Chemical]

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid
763114-26-7

2-fluoro-5-[(4’-oxo-3’H-phthalazin-1’-yl)methyl]benzoic acid

olaparib
763113-22-0

olaparib

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
1.2: 72 h / 50 °C / Inert atmosphere
2.1: hydrogenchloride / water; ethanol / 20 °C / Inert atmosphere
3.1: triethylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
3.2: 72 h / 20 °C / Inert atmosphere
With hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In ethanol; water; N,N-dimethyl-formamide;
 
Multi-step reaction with 3 steps
1: thionyl chloride; triethylamine / dichloromethane / 0 - 20 °C
2: isopropyl alcohol / 20 °C
3: acetonitrile
With thionyl chloride; triethylamine; In dichloromethane; isopropyl alcohol; acetonitrile;
 
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / acetone / 1 h / 20 - 30 °C
2.1: acetone / 1 h / 20 °C
3.1: acetone; water / 4 h / 56.9 - 65 °C
4.1: potassium carbonate / ethyl acetate; water / 1 h / 20 °C
4.2: 2 h / 20 °C
With potassium carbonate; N-ethyl-N,N-diisopropylamine; In water; ethyl acetate; acetone;
 
Multi-step reaction with 3 steps
1: thionyl chloride; N,N-dimethyl-formamide / 4 h / Reflux
2: dichloromethane / 3 h / -5 - 5 °C
3: triethylamine / dichloromethane / 1 h / -5 - 5 °C
With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
 
bromobenzene
108-86-1,52753-63-6

bromobenzene

olaparib
763113-22-0

olaparib

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / toluene / 3 h / 90 °C
1.2: 24 h / 110 °C
2.1: C6H11N2(1+)*Cl(1-)*AlCl3 / 50 - 55 °C / Inert atmosphere
With C6H11N2(1+)*Cl(1-)*AlCl3; potassium tert-butylate; In toluene;
 
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / toluene / 3 h / 90 °C
1.2: 24 h / 110 °C
2.1: C6H11N2(1+)*Cl(1-)*AlCl3 / 50 - 55 °C
With C6H11N2(1+)*Cl(1-)*AlCl3; potassium tert-butylate; In toluene;
 

2.What is the CAS number for Olaparib ?

The CAS number of Olaparib is 763113-22-0.

More information of Olaparib 763113-22-0 are:

CAS Number

 763113-22-0

Density

 1.43 g/cm3

Refractive Index

 1.702

HS CODE

 29339900

PSA

 86.37000

LogP

 2.22320

Pka

 12.07±0.40(Predicted)

3.What are another words for Olaparib ?

Synonyms for Olaparib 763113-22-0:4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one;1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]piperazine;

4.What is the molecular formula of Olaparib?

The chemical formula of  Olaparib is C24H23FN4O3 which containing 24 Carbon atoms,23 Hydrogen atoms,1 Fluorine atoms,4 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of  Olaparib is 434.47.

5.What is Olaparib (763113-22-0) used for?

Many of the products generated by alkylating agents on DNA can be efficiently repaired by normal base excision repair (BER). Some poly(ADP-ribose) polymerases (PARPs) assist in the repair of single-strand DNA nicks, an important step in BER. Olaparib is a potent inhibitor of PARP1 and PARP2 (IC50 = 5 and 1 nM, respectively) but is less effective against the PARP tankyrase-1 (IC50 = 1.5 μM). It can be used in cells and in animals, alone or in combination therapy with alkylating agents, to block BER and increase cancer cell death.

InChI:InChI=1/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)

Relevant articles related to Olaparib:

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6.Buy Olaparib with the best price .

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