53772-83-1

  • Product Name:Zuclopenthixol
  • Molecular Formula:C22H25ClN2OS
  • Molecular Weight:400.972
Inquiry

Product Details

pd_meltingpoint:56-60°C

Purity:99%

Quality Factory Sells Top Purity 99% Zuclopenthixol 53772-83-1 with Safe Delivery

  • Molecular Formula:C22H25ClN2OS
  • Molecular Weight:400.972
  • Vapor Pressure:3.56E-14mmHg at 25°C 
  • Melting Point:56-60°C 
  • Refractive Index:1.675 
  • Boiling Point:577.4 °C at 760 mmHg 
  • PKA:14.96±0.10(Predicted) 
  • Flash Point:303 °C 
  • PSA:52.01000 
  • Density:1.289 g/cm3 
  • LogP:4.11210 

Zuclopenthixol(Cas 53772-83-1) Usage

Drug interactions

Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effects. Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids; increased risk of ventricular arrhythmias with methadone. Anti-arrhythmics: increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval - avoid with amiodarone and disopyramide. Antibacterials: increased risk of ventricular arrhythmias with moxifloxacin and parenteral erythromycin - avoid Antidepressants: increased level of tricyclics; possible increased risk of convulsions with vortioxetine. Antiepileptics: anticonvulsant effect antagonised. Antimalarials: avoid concomitant use with artemether/lumefantrine. Antipsychotics: avoid concomitant use of clozapine with depot preparations in case of neutropenia; possible increased risk of ventricular arrhythmias with risperidone. Antivirals: concentration possibly increased with ritonavir. Atomoxetine: increased risk of ventricular arrhythmias. Anxiolytics and hypnotics: increased sedative effects. Beta-blockers: increased risk of ventricular arrhythmias with sotalol - avoid. Cytotoxics: increased risk of ventricular arrhythmias with vandetanib - avoid; increased risk of ventricular arrhythmias with arsenic trioxide.

Metabolism

Metabolism of zuclopenthixol is by sulphoxidation, sidechain N-dealkylation and glucuronic acid conjugation. The sulphoxide metabolites are mainly excreted in the urine while unchanged drug and the dealkylated form tend to be excreted in the faeces.

Definition

ChEBI: The (Z)-isomer of clopenthixol.

InChI:InChI=1/C22H25ClN2OS/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26/h1-2,4-8,16,26H,3,9-15H2/b18-5-

53772-83-1 Relevant articles

Enantioselective Allylation Using Allene, a Petroleum Cracking Byproduct

Liu, Richard Y.,Zhou, Yujing,Yang, Yang,Buchwald, Stephen L.

supporting information, p. 2251 - 2256 (2019/03/05)

Allene (C3H4) gas is produced and separa...

53772-83-1 Process route

4-[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]-1-piperazineethanol
982-24-1,53772-83-1,53772-84-2

4-[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]-1-piperazineethanol

Conditions
Conditions Yield
2-Chlor-9-<3-piperazino-propyliden>-thioxanthen, Aethylenoxid;
2-Chlor-9-allyl-thioxanthen-9-ol, 1) SOCl2, 2) N-<2-Hydroxy-aethyl>-piperazin;
tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate
77278-40-1

tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate

2-Chlorothioxanthone
86-39-5

2-Chlorothioxanthone

1,2-propanediene
463-49-0

1,2-propanediene

2-bromoethanol
540-51-2

2-bromoethanol

clopenthixol
53772-83-1,53772-84-2

clopenthixol

zuclopenthixol
53772-83-1,53772-84-2

zuclopenthixol

Conditions
Conditions Yield
2-Chlorothioxanthone; With copper diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; for 0.0833333h; Inert atmosphere;
1,2-propanediene; With (dimethoxy)methylsilane; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere; Schlenk technique;
tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate; 2-bromoethanol; Overall yield = 54 %; Overall yield = 217 mg; Further stages;
4.762 % de

53772-83-1 Upstream products

  • 77278-40-1
    77278-40-1

    tert-butyl 4-(benzoyloxy)piperazine-1-carboxylate

  • 86-39-5
    86-39-5

    2-Chlorothioxanthone

  • 463-49-0
    463-49-0

    1,2-propanediene

  • 540-51-2
    540-51-2

    2-bromoethanol

53772-83-1 Downstream products

  • 85721-05-7
    85721-05-7

    zuclopenthixol acetate

Relevant Products