PP242 is , while it's Molecular Formula is C16H16N6O. PP 242 is used in leukemia therapy suppressing mTOR signaling. Dual mTORC1/C2 inhibitor.

What is the CAS number for PP242?

The CAS number of PP242 is 1092351-67-1.

What is PP242 (1092351-67-1) used for?

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin) and regulate different pathways. PP242 is an inhibitor of the active site of mTOR kinase in both mTORC1 and mTORC2 (IC50 = 8 nM). It less effectively inhibits PKCα, PI3-kinase subunit p110γ, JAK2, PKCβI, and PKCβII (IC50 = 49, 102, 110, 198, and 185, respectively). PP242 has been shown to cause the death of certain human and murine leukemia cells more potently than rapamycin and, in vivo, delays leukemia onset and augments the effects of tyrosine kinase inhibitors in suppressing leukemic expansion and extending survival.

PP242 is , while it's Molecular Formula is C16H16N6O. PP 242 is used in leukemia therapy suppressing mTOR signaling. Dual mTORC1/C2 inhibitor.

What is the CAS number for PP242?

The CAS number of PP242 is 1092351-67-1.

What is PP242 (1092351-67-1) used for?

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin) and regulate different pathways. PP242 is an inhibitor of the active site of mTOR kinase in both mTORC1 and mTORC2 (IC50 = 8 nM). It less effectively inhibits PKCα, PI3-kinase subunit p110γ, JAK2, PKCβI, and PKCβII (IC50 = 49, 102, 110, 198, and 185, respectively). PP242 has been shown to cause the death of certain human and murine leukemia cells more potently than rapamycin and, in vivo, delays leukemia onset and augments the effects of tyrosine kinase inhibitors in suppressing leukemic expansion and extending survival.

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1092351-67-1

Product Name:PP242
Molecular Formula:C16H16N6O
Molecular Weight:308.34

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Product Details

Purity:99%

Factory Supply industrial standard PP242 1092351-67-1 In Stock

Molecular Formula:C16H16N6O
Molecular Weight:308.34
Boiling Point:642.045 °C at 760 mmHg
PKA:9.51±0.40(Predicted)
Flash Point:342.097 °C
PSA：105.64000
Density:1.557 g/cm³
LogP:3.42450

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