What is the 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol?

4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol is , while it's Molecular Formula is C 33 H 31 F 3 N 6 O 2 . Used in Pharmaceutical Industry: 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol is used as a potential pharmaceutical agent for [application reason]. Its complex molecular structure, including the fluorine substituent, naphthalenol moiety, and various functional groups, may contribute to its activity against specific biological targets or diseases. Used in Research and Development: In the field of chemical research and development, 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol serves as a subject of study for understanding its chemical properties, reactivity, and potential applications. Its unique structure may offer insights into the design of new compounds with specific functions or therapeutic effects.

What is the CAS number for 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol?

The CAS number of 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol is 2621928-55-8.

What is 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol (2621928-55-8) used for?

4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol is a complex organic compound characterized by a unique molecular structure. It features a fluorine substituent, a naphthalenol moiety, and a diazabicyclooctane ring system, along with various functional groups such as pyrimidine, pyridine, and pyrrolizin. The presence of these structural elements suggests potential pharmaceutical or biological applications for this compound. Further research and analysis are required to fully explore its properties and possible uses.

What is the 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol?

4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol is , while it's Molecular Formula is C 33 H 31 F 3 N 6 O 2 . Used in Pharmaceutical Industry: 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol is used as a potential pharmaceutical agent for [application reason]. Its complex molecular structure, including the fluorine substituent, naphthalenol moiety, and various functional groups, may contribute to its activity against specific biological targets or diseases. Used in Research and Development: In the field of chemical research and development, 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol serves as a subject of study for understanding its chemical properties, reactivity, and potential applications. Its unique structure may offer insights into the design of new compounds with specific functions or therapeutic effects.

What is the CAS number for 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol?

The CAS number of 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol is 2621928-55-8.

What is 4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol (2621928-55-8) used for?

4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol is a complex organic compound characterized by a unique molecular structure. It features a fluorine substituent, a naphthalenol moiety, and a diazabicyclooctane ring system, along with various functional groups such as pyrimidine, pyridine, and pyrrolizin. The presence of these structural elements suggests potential pharmaceutical or biological applications for this compound. Further research and analysis are required to fully explore its properties and possible uses.

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2621928-55-8

Product Name:MRTX1133，
Molecular Weight:600.643

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Product Details

Purity:99%

Factory Sells Best Quality MRTX1133， 2621928-55-8 with GMP standards

Molecular Formula:C₃₃H₃₁F₃N₆O₂
Molecular Weight:600.643

2621928-55-8 Relevant articles

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12DInhibitor

Wang, Xiaolun,Allen, Shelley,Blake, James F.,Bowcut, Vickie,Briere, David M.,Calinisan, Andrew,Dahlke, Joshua R.,Fell, Jay B.,Fischer, John P.,Gunn, Robin J.,Hallin, Jill,Laguer, Jade,Lawson, J. David,Medwid, James,Newhouse, Brad,Nguyen, Phong,O'Leary, Jacob M.,Olson, Peter,Pajk, Spencer,Rahbaek, Lisa,Rodriguez, Mareli,Smith, Christopher R.,Tang, Tony P.,Thomas, Nicole C.,Vanderpool, Darin,Vigers, Guy P.,Christensen, James G.,Marx, Matthew A.

, p. 3123 - 3133 (2021/12/27)

KRASG12D, the most common oncogenic KRAS...

KRAS G12D INHIBITORS

-

Paragraph 0917, (2021/03/05)

The present invention relates to compoun...

2621928-55-8 Process route

: 4-(4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-6-fluoro-5-((triisopropylsilyl)ethynyl)naphthalen-2-ol

: 2621928-55-8
4-(4-(3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol

Conditions

Conditions	Yield
With cesium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;	4.88 mg

: (1R,5S)-tert-butyl 3-(7-(8-ethynyl-7-fluoro-3-(methoxymethoxy)naphthalen-1-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate

: 2621928-55-8
4-(4-((1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol

Conditions

Conditions	Yield
With hydrogenchloride; In 1,4-dioxane; acetonitrile; at 0 ℃; for 1h; Inert atmosphere;	56%

2621928-55-8 Upstream products

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