What is the PLX3397 (Pexidartinib)?

PLX3397 (Pexidartinib) is , while it's Molecular Formula is C20H15ClF3N5. Pexidartinib is RTK inhibitor. It can be used in pharmacological activity, therapeutic use, and biological study of inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.

What is the CAS number for PLX3397 (Pexidartinib)?

The CAS number of PLX3397 (Pexidartinib) is 1029044-16-3.

What is PLX3397 (Pexidartinib) (1029044-16-3) used for?

Colony stimulating factor 1 (CSF1) is a cytokine that is involved in the recruitment and activation of tissue macrophages. It exerts these effects by binding to its corresponding receptor tyrosine kinase, the cFMS/CSF1 receptor (CSF1R). Pexidartinib is a brain-penetrant inhibitor of CSF1R, as well as c-Kit and FLT3 (IC50s = 20, 10, and 160 nM in vitro, respectively). It has been used in combination with paclitaxel to block macrophage recruitment in mammary tumor-bearing mice, thus slowing primary tumor development and metastasis. Pexidartinib has also been used to block microglial stimulation of glioblastoma invasion in both cell culture and a mouse model of glioblastoma multiforme.

What is the PLX3397 (Pexidartinib)?

PLX3397 (Pexidartinib) is , while it's Molecular Formula is C20H15ClF3N5. Pexidartinib is RTK inhibitor. It can be used in pharmacological activity, therapeutic use, and biological study of inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.

What is the CAS number for PLX3397 (Pexidartinib)?

The CAS number of PLX3397 (Pexidartinib) is 1029044-16-3.

What is PLX3397 (Pexidartinib) (1029044-16-3) used for?

Colony stimulating factor 1 (CSF1) is a cytokine that is involved in the recruitment and activation of tissue macrophages. It exerts these effects by binding to its corresponding receptor tyrosine kinase, the cFMS/CSF1 receptor (CSF1R). Pexidartinib is a brain-penetrant inhibitor of CSF1R, as well as c-Kit and FLT3 (IC50s = 20, 10, and 160 nM in vitro, respectively). It has been used in combination with paclitaxel to block macrophage recruitment in mammary tumor-bearing mice, thus slowing primary tumor development and metastasis. Pexidartinib has also been used to block microglial stimulation of glioblastoma invasion in both cell culture and a mouse model of glioblastoma multiforme.

Product classification

Contact us

Tel：+86-0533-2185556
Fax：+86-0533-2185556
Phone：+86 15965530500
Website：http://www.shandonghangyu.com/
Email：admin@hangyubiotech.com
Address：Room 2516, Dingcheng Building, Beijing Road, Zhangdian District, Zibo City, Shandong Province

1029044-16-3

Product Name:PLX3397 (Pexidartinib)
Molecular Formula:C20H15ClF3N5
Molecular Weight:417.821

Inquiry

Product Details

Purity:99%

Chinese Manufacturer supply PLX3397 (Pexidartinib) 1029044-16-3 in stock with high standard

Molecular Formula:C20H15ClF3N5
Molecular Weight:417.821
PKA:12.81±0.40(Predicted)
PSA：66.49000
Density:1.458±0.06 g/cm3(Predicted)
LogP:5.30100

1029044-16-3 Relevant articles

Exploratory Process Development of Pexidartinib through the Tandem Tsuji-Trost Reaction and Heck Coupling

Chen, Dongsheng,Li, Jianqi,Liu, Yu,Zhang, Yi

, p. 2564 - 2571 (2019)

A novel synthetic route to CSF1R inhibit...

Dealkenylative Ni-Catalyzed Cross-Coupling Enabled by Tetrazine and Photoexcitation

Cao, Yuhui,Che, Jinteng,Chen, Han,Chen, Si-Cong,Fang, Xianhe,Guo, Yinliang,Guo, Zhixian,Kong, Lingran,Li, Chen,Lu, Jia-Tian,Luo, Tuoping,Zhang, Nan,Zhu, Qi

, p. 14046 - 14052 (2021/09/13)

A new and general method to functionaliz...

Intermediate for preparing pexidartinib, and preparation method and application thereof

-

Paragraph 0179-0181, (2020/07/12)

The invention discloses an intermediate ...

Synthetic method for continuously producing pexidartinib

-

Paragraph 0040-0044; 0047-0052; 0055-0060; 0063, (2020/06/20)

The invention relates to the field of ch...

1029044-16-3 Process route

: C₂₀H₁₅ClF₃N₅O₃

: 1029044-16-3
5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine

Conditions

Conditions	Yield
With 5%-palladium/activated carbon; hydrogen; ammonium chloride; In methanol; at 30 - 35 ℃; for 6h; under 1500.15 - 2250.23 Torr; Solvent; Reagent/catalyst; Temperature; Autoclave; Green chemistry;	98.1%

: 5-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine

: 386704-12-7,872626-76-1
6-(trifluoromethyl)pyridine-3-carbaldehyde

: 1029044-16-3
5-((5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine

Conditions

Conditions	Yield
With triethylsilane; trifluoroacetic acid; In acetonitrile; at 15 - 82 ℃;	89.4%
With triethylsilane; trifluoroacetic acid; In acetonitrile; at 65 ℃; for 36h;	89%
With sodium tetrahydroborate; acetic acid; In methanol;	86%

1029044-16-3 Upstream products

666721-10-4
tert-butyl N-[(tert-butoxy)carbonyl]-N-(5-formylpyridin-2-yl)carbamate
866546-07-8
5-chloro-1H-pyrrolo[2,3-b]pyridine
2040295-05-2
C₂₃H₂₇ClN₄O₅
386704-12-7
6-(trifluoromethyl)pyridine-3-carbaldehyde

Relevant Products

Romifidine
CAS：65896-14-2
1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)-
CAS：1231930-42-9
SINENSETIN
CAS：2306-27-6
BENZENEMETHANESULFONYL CHLORIDE, 4-METHOXY-
CAS：110661-59-1