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280749-17-9

  • Product Name:A 286982
  • Molecular Formula:C24H27N3O4S
  • Molecular Weight:453.55400
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Product Details

Purity:99%

High quality purity >99% A 286982 280749-17-9 for sale

  • Molecular Formula:C24H27N3O4S
  • Molecular Weight:453.55400
  • PSA：111.74000 
  • LogP:4.97230 

280749-17-9 Relevant articles

Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds

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Page 38, (2010/02/07)

The present invention relates to novel c...

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead

Liu,Link,Pei,Reilly,Leitza,Nguyen,Marsh,Okasinski,Von Geldern,Ormes,Fowler,Gallatin

, p. 4025 - 4040 (2007/10/03)

The interaction between leukocyte functi...

280749-17-9 Process route

2-isopropylbenzenethiol
6262-87-9

2-isopropylbenzenethiol

1-chloro-2-nitro-4-((E)-((4-acetylpiperazin-1-yl)carbonyl)ethenyl)benzene
301179-69-1

1-chloro-2-nitro-4-((E)-((4-acetylpiperazin-1-yl)carbonyl)ethenyl)benzene

(2-iso-propylphenyl)[2-nitro-4-(E-((4-acetylpiperazin-1-yl)carbonyl)ethenyl)phenyl]sulfide
280749-17-9

(2-iso-propylphenyl)[2-nitro-4-(E-((4-acetylpiperazin-1-yl)carbonyl)ethenyl)phenyl]sulfide

Conditions
Conditions Yield
With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
N-acetylpiperidine
13889-98-0

N-acetylpiperidine

(2-iso-propylphenyl)[2-nitro-4-(E-((4-acetylpiperazin-1-yl)carbonyl)ethenyl)phenyl]sulfide
280749-17-9

(2-iso-propylphenyl)[2-nitro-4-(E-((4-acetylpiperazin-1-yl)carbonyl)ethenyl)phenyl]sulfide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 91.6 percent / EDAC / dimethylformamide / 2 h / 20 °C
2: K2CO3 / dimethylformamide / 1 h / 20 °C
With potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; 1: Acylation / 2: Substitution;

280749-17-9 Upstream products

  • 6262-87-9
    6262-87-9

    2-isopropylbenzenethiol

  • 301179-69-1
    301179-69-1

    1-chloro-2-nitro-4-((E)-((4-acetylpiperazin-1-yl)carbonyl)ethenyl)benzene

  • 13889-98-0
    13889-98-0

    N-acetylpiperidine

  • 20797-48-2
    20797-48-2

    (E)-4-chloro-3-nitrocinnamic acid

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