CRT5 is , while it's Molecular Formula is C 28 H 30 N 4 O 2 . CRT5 is used in the characterization of biological effects of a novel protein kinase D inhibitor in endothelial cells.

What is the CAS number for CRT5?

The CAS number of CRT5 is 1034297-58-9.

What is CRT5 (1034297-58-9) used for?

Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). It has little effect on a panel of additional kinases when given at 1 μM. CRT5 blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation or PKD autophosphorylation. It also decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis.

CRT5 is , while it's Molecular Formula is C 28 H 30 N 4 O 2 . CRT5 is used in the characterization of biological effects of a novel protein kinase D inhibitor in endothelial cells.

What is the CAS number for CRT5?

The CAS number of CRT5 is 1034297-58-9.

What is CRT5 (1034297-58-9) used for?

Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling. The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). It has little effect on a panel of additional kinases when given at 1 μM. CRT5 blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation or PKD autophosphorylation. It also decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis.

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1034297-58-9

Product Name:CRT5
Molecular Weight:454.572

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Product Details

Purity:99%

CRT5 Good Supplier In Bulk Supply High Purity 1034297-58-9

Molecular Formula:C₂₈H₃₀N₄O₂
Molecular Weight:454.572
Boiling Point:651.2±55.0 °C(Predicted)
PKA:14.23±0.46(Predicted)
Density:1.173±0.06 g/cm3(Predicted)

1034297-58-9 Relevant articles

PYRIDINE BENZAMIDES AND PYRAZINE BENZAMIDES USED AS PKD INHIBITORS

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Page/Page column 101-102, (2008/12/06)

The present invention pertains generally...

1034297-58-9 Process route

: 1034297-58-9
CRT5

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