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103060-53-3

  • Product Name:Daptomycin
  • Molecular Formula:C72H101 N17 O26
  • Molecular Weight:1620.69
  • Appearance:White powder
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Product Details

pd_meltingpoint:202-204?C

Appearance:White powder

Purity:99%

Reputable manufacturer supply Daptomycin 103060-53-3 in stock with high standard

  • Molecular Formula:C72H101 N17 O26
  • Molecular Weight:1620.69
  • Appearance/Colour:White powder 
  • Melting Point:202-204?C 
  • Boiling Point:2078.2 °C at 760 mmHg 
  • PKA:4.00±0.10(Predicted) 
  • Flash Point:1210.7 °C 
  • PSA：702.02000 
  • Density:1.45 g/cm3 
  • LogP:0.88280 

103060-53-3 Relevant articles

Solid-phase total synthesis of daptomycin and analogs

Lohani, Chuda Raj,Taylor, Robert,Palmer, Michael,Taylor, Scott D.

, p. 748 - 751 (2015)

An entirely solid-phase synthesis of dap...

103060-53-3 Process route

1-decanoic acid
334-48-5

1-decanoic acid

N-(fluoren-9-ylmethoxycarbonyl)glycine
29022-11-5

N-(fluoren-9-ylmethoxycarbonyl)glycine

(2S,3R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-3-methyl-5-oxopentanoic acid
1429504-34-6

(2S,3R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-3-methyl-5-oxopentanoic acid

C<sub>23</sub>H<sub>20</sub>N<sub>4</sub>O<sub>3</sub>

C23H20N4O3

C<sub>62</sub>H<sub>58</sub>N<sub>4</sub>O<sub>15</sub>

C62H58N4O15

N-(9-fluorenylmethoxycarbonyl)-D-alanine
35661-38-2,35661-39-3,79990-15-1,136132-75-7

N-(9-fluorenylmethoxycarbonyl)-D-alanine

Fmoc-Thr-OH
73731-37-0

Fmoc-Thr-OH

(R)-N-(fluoren-9-ylmethoxycarbonyl)serine
73724-45-5,136083-72-2,116861-26-8

(R)-N-(fluoren-9-ylmethoxycarbonyl)serine

Fmoc-Orn(Boc)-OH
109425-55-0,118476-89-4

Fmoc-Orn(Boc)-OH

p-toluenesulfonic acid salt of glycine allyl ester
88223-98-7

p-toluenesulfonic acid salt of glycine allyl ester

(S)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-(allyloxy)-4-oxobutanoic acid
144120-53-6

(S)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-(allyloxy)-4-oxobutanoic acid

4-(1,1-dimethylethyl) ester of Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid allyl ester
144120-52-5

4-(1,1-dimethylethyl) ester of Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid allyl ester

(S)-(?)-4-tert-butyl 2-azidosuccinic acid
333366-23-7

(S)-(?)-4-tert-butyl 2-azidosuccinic acid

(S)-2-azido-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)propanoic acid

(S)-2-azido-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)propanoic acid

daptomycin
103060-53-3

daptomycin

Conditions
Conditions Yield
(S)-3-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-(allyloxy)-4-oxobutanoic acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 4h; 2-chlorotrityl chloride resin
With tetrakis(triphenylphosphine) palladium(0); 1,3-dimethylbarbituric acid; In dichloromethane; N,N-dimethyl-formamide; for 1h; 2-chlorotrityl chloride resin
1-decanoic acid; N-(fluoren-9-ylmethoxycarbonyl)glycine; (2S,3R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-3-methyl-5-oxopentanoic acid; C23H20N4O3; C62H58N4O15; N-(9-fluorenylmethoxycarbonyl)-D-alanine; Fmoc-Thr-OH; (R)-N-(fluoren-9-ylmethoxycarbonyl)serine; Fmoc-Orn(Boc)-OH; p-toluenesulfonic acid salt of glycine allyl ester; 4-(1,1-dimethylethyl) ester of Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid allyl ester; (S)-(?)-4-tert-butyl 2-azidosuccinic acid; (S)-2-azido-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)propanoic acid; Further stages;
9%
daptomycin
103060-53-3

daptomycin

C<sub>82</sub>H<sub>102</sub>N<sub>6</sub>O<sub>16</sub>

C82H102N6O16

C<sub>153</sub>H<sub>199</sub>N<sub>23</sub>O<sub>42</sub>

C153H199N23O42

Conditions
Conditions Yield
C82H102N6O16; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at 0 ℃; for 1h;
daptomycin; With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 - 20 ℃;
48%

103060-53-3 Upstream products

  • 334-48-5
    334-48-5

    1-decanoic acid

  • 29022-11-5
    29022-11-5

    N-(fluoren-9-ylmethoxycarbonyl)glycine

  • 1429504-34-6
    1429504-34-6

    (2S,3R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-(tert-butoxy)-3-methyl-5-oxopentanoic acid

  • 35661-38-2
    35661-38-2

    N-(9-fluorenylmethoxycarbonyl)-D-alanine

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