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1297538-32-9

  • Product Name:Darolutamide
  • Molecular Formula:C19H19ClN6O2
  • Molecular Weight:398.852
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Product Details

Purity:99%

China cas 1297538-32-9 factory wholesale Darolutamide at affordable price

  • Molecular Formula:C19H19ClN6O2
  • Molecular Weight:398.852
  • Boiling Point:719.5±60.0 °C(Predicted) 
  • PKA:11.10±0.10(Predicted) 
  • PSA：119.62000 
  • Density:1.41±0.1 g/cm3(Predicted) 
  • LogP:3.06098 

1297538-32-9 Relevant articles

Pyrazoleamide derivative and synthesis method and application

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, (2022/01/10)

The present invention discloses a pyrazo...

Synthesis method of polyamidoamine (by machine translation)

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Paragraph 0094-0097, (2020/05/11)

To the synthesis method, acetyl - 2 2-ch...

Synthesis process of darolutamide

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, (2020/05/30)

The invention relates to a synthesis pro...

Method for preparing antitumor drug darolutamide

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Paragraph 0059-0065, (2020/05/30)

The invention relates to a method for pr...

1297538-32-9 Process route

5-(1-((tert-butyldimethylsilyl)oxy)ethyl)-N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

5-(1-((tert-butyldimethylsilyl)oxy)ethyl)-N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1H-pyrazole-3-carboxamide

N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide
1297538-32-9

N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide

Conditions
Conditions Yield
With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 6h;
92.9%
C<sub>21</sub>H<sub>21</sub>ClN<sub>6</sub>O<sub>3</sub>

C21H21ClN6O3

N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide
1297538-32-9

N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide

Conditions
Conditions Yield
With sodium hydroxide; In ethanol; water; at 20 ℃;
93.3%

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