What is the N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide?

N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide is , while it's Molecular Formula is C 21 H 20 F 3 N 7 O 3 S. PF-56227 is a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK). Potent FAK inhibitor.

What is the CAS number for N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide?

The CAS number of N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide is 717907-75-0.

What is N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide (717907-75-0) used for?

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

What is the N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide?

N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide is , while it's Molecular Formula is C 21 H 20 F 3 N 7 O 3 S. PF-56227 is a potent, ATP-competitive, reversible inhibitor of focal adhesion kinase (FAK). Potent FAK inhibitor.

What is the CAS number for N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide?

The CAS number of N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide is 717907-75-0.

What is N-Methyl-N-[3-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]pyridin-2-yl]methanesulfonamide (717907-75-0) used for?

PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

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717907-75-0

Product Name:PF562271
Molecular Formula:C₂₁H₂₀F₃N₇O₃S
Molecular Weight:507.496

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Product Details

Purity:99%

China cas 717907-75-0 manufacturer wholesale PF562271 at affordable price

Molecular Formula:C₂₁H₂₀F₃N₇O₃S
Molecular Weight:507.496
PKA:13.66±0.20(Predicted)
PSA：137.59000
Density:1.54 g/cm³
LogP:4.50130

717907-75-0 Relevant articles

Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2

Berger, Benedict-Tilman,Amaral, Marta,Kokh, Daria B.,Nunes-Alves, Ariane,Musil, Djordje,Heinrich, Timo,Schr?der, Martin,Neil, Rebecca,Wang, Jing,Navratilova, Iva,Bomke, Joerg,Elkins, Jonathan M.,Müller, Susanne,Frech, Matthias,Wade, Rebecca C.,Knapp, Stefan

, p. 686 - 7,698 (2021/02/16)

There is increasing evidence of a signif...

PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

-

Page/Page column 8, (2011/02/26)

The present invention relates to salts, ...

Pyrimidine derivatives for the treatment of abnormal cell growth

-

Page/Page column 44, (2008/06/13)

The present invention relates to a compo...

717907-75-0 Process route

: 717907-76-1
5-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-2,3-dihydro-1H-indol-2-one

: N-(3-Aminomethyl-2-pyridyl)-N-methylmethanesulfonamide diacetate

: 717907-75-0
PF-562,271

Conditions

Conditions	Yield
With diisopropylamine; In isopropyl alcohol; toluene; at 10 - 90 ℃; for 6.4h; Industry scale;	68.3%

: 717907-76-1
5-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-2,3-dihydro-1H-indol-2-one

: N-(3-aminomethyl-pyridin-2-yl)-N-methyl-methanesulfonamide dihydrochloride

: 717907-75-0
PF-562,271

Conditions

Conditions	Yield
With sodium carbonate; In N,N-dimethyl-formamide; at 85 ℃;	36%

717907-75-0 Upstream products

717907-76-1
5-{[4-chloro-5-(trifluoromethyl)pyrimidin-2-yl]amino}-2,3-dihydro-1H-indol-2-one
54-20-6
5-trifluoromethyluracil
3932-97-6
2,4-dichloro-5-trifluoromethylpyrimidine
20876-36-2
5-amino-1,3-dihydro-2H-indol-2-one

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