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Purity:99%
InChI:InChI=1/C9H17NO2/c10-7-8-1-3-9(4-2-8)11-5-6-12-9/h8H,1-7,10H2
Reductive homologation of 1,4-cyclohexan...
3-(2-Amino-4-methylthiazol-5-yl)propyl-s...
The present invention comprises compound...
The present invention comprises compound...
The present invention comprises compound...
1,4-dioxaspiro<4.5>decane-8-carbonitrile
![(1,4-dioxa-spiro[4.5]dec-8-yl)-methyl-amine](/upload/2026/5/dd8c063d-2862-4654-ab2c-7a470d3ce98b.png)
(1,4-dioxa-spiro[4.5]dec-8-yl)-methyl-amine
| Conditions | Yield |
|---|---|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 15h;
Cooling with ice;
Reflux;
|
99% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 2h;
Heating;
|
85% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
1) reflux, 2 h, 2) r.t., 12 h.;
|
80% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
Heating;
|
77% |
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
|
75% |
|
1,4-dioxaspiro<4.5>decane-8-carbonitrile;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 2h;
Heating / reflux;
With
sodium hydroxide; water;
In
tetrahydrofuran;
|
|
|
1,4-dioxaspiro<4.5>decane-8-carbonitrile;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 65 ℃;
for 24h;
With
water; sodium hydroxide;
at 0 - 20 ℃;
for 1h;
|
|
|
1,4-dioxaspiro<4.5>decane-8-carbonitrile;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 65 ℃;
for 12h;
With
sodium hydroxide;
In
water;
at 20 ℃;
for 1h;
With
magnesium sulfate;
In
water;
at 20 ℃;
for 2h;
|
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 65 ℃;
for 24h;
|
1,4-dioxaspiro<4,5>decane-8-carboxamide
(1,4-dioxa-spiro[4.5]dec-8-yl)-methyl-amine
| Conditions | Yield |
|---|---|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 2h;
Heating;
|
74% |
|
In
tetrahydrofuran; dichloromethane; water;
|
1,4-dioxaspiro<4,5>decane-8-carboxamide
1,4-dioxaspiro<4.5>decane-8-carbonitrile
cyclohexanedione monoethylene ketal
(1,4-dioxaspiro[4.5]dec-8-yl)methanol
1-azaadamantane-4-one
2-[(4-oxocyclohexyl)methyl]isoindoline-1,3-dione
1,4-dioxaspiro<4.5>decane-8-carbonitrile
2-{[4-(hydroxyimino)cyclohexyl]methyl}isoindoline-1,3-dione
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