What is the Rolapitant?

Rolapitant is , while it's Molecular Formula is C25H26F6N2O2. Used in Pharmaceutical Industry: Rolapitant is used as an antiemetic agent for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy. It works by blocking the neurokinin-1 (NK-1) receptor, which is involved in the vomiting reflex, thus providing relief to patients undergoing cancer treatment.

What is the CAS number for Rolapitant?

The CAS number of Rolapitant is 552292-08-7.

What is Rolapitant (552292-08-7) used for?

Rolapitant is an azaspiro compound, specifically 1,7-diazaspiro[4.5]decan-2-one, with additional phenyl and 1-[3,5-bis(trifluoromethyl)phenyl]ethoxymethyl substituents at position 8. It is used in the form of the hydrochloride hydrate for medical purposes.

What is the Rolapitant?

Rolapitant is , while it's Molecular Formula is C25H26F6N2O2. Used in Pharmaceutical Industry: Rolapitant is used as an antiemetic agent for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy. It works by blocking the neurokinin-1 (NK-1) receptor, which is involved in the vomiting reflex, thus providing relief to patients undergoing cancer treatment.

What is the CAS number for Rolapitant?

The CAS number of Rolapitant is 552292-08-7.

What is Rolapitant (552292-08-7) used for?

Rolapitant is an azaspiro compound, specifically 1,7-diazaspiro[4.5]decan-2-one, with additional phenyl and 1-[3,5-bis(trifluoromethyl)phenyl]ethoxymethyl substituents at position 8. It is used in the form of the hydrochloride hydrate for medical purposes.

Product classification

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552292-08-7

Product Name:Rolapitant
Molecular Formula:C25H26F6N2O2
Molecular Weight:500.484

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Product Details

Purity:99%

Reputable manufacturer supply Rolapitant 552292-08-7 in stock with high standard

Molecular Formula:C25H26F6N2O2
Molecular Weight:500.484
Boiling Point:523.5±50.0 °C(Predicted)
PKA:15.88±0.40(Predicted)
PSA：50.36000
Density:1.34±0.1 g/cm3(Predicted)
LogP:6.38710

552292-08-7 Relevant articles

A NK - 1 receptor antagonists of the preparation method and its intermediate

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, (2018/07/30)

The invention relates to a preparation m...

Synthesis method of rolapitant

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Paragraph 0006; 0018; 0019, (2018/03/01)

The invention provides a synthesis metho...

And as the antagonist aminopyrrolidine deriv. NK1 aminopiperidine (by machine translation)

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Paragraph 0582-0590, (2016/10/08)

A NK 1 antagonist having the formula (I...

PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF 8-[-METHYL]-8-PHENYL-1,7-DIAZA-SPIRO[4.5]DECAN-2-ONE COMPOUNDS

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Page/Page column 15, (2010/04/30)

This application discloses a novel proce...

552292-08-7 Process route

: C₄₂H₄₄F₆N₂O₅

: 552292-08-7
Rolapitant

Conditions

Conditions	Yield
With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; under 3800.26 Torr; Autoclave; Large scale;	92.9%

: 1297609-87-0
(S)-1-bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethane

: (5S,8S)-8-hydroxymethyl-8-phenyl-7-trifluoroacetyl-1,7-diazaspiro[4.5]nonan-2-one

: 552292-08-7
Rolapitant

Conditions

Conditions	Yield
(5S,8S)-8-hydroxymethyl-8-phenyl-7-trifluoroacetyl-1,7-diazaspiro[4.5]nonan-2-one; With sodium hydride; In N,N-dimethyl acetamide; at 0 - 5 ℃; for 0.5h; (S)-1-bromo-1-[3,5-bis(trifluoromethyl)phenyl]ethane; In N,N-dimethyl acetamide;	90%

552292-08-7 Upstream products

1065272-06-1
methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate
552293-48-8
C₃₆H₄₀F₆N₂O₆
552293-37-5
C₃₀H₂₇F₆NO₄

552292-08-7 Downstream products

951390-98-0
(5S,8S)-8-[{(1R)-1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one maleate
951390-97-9
(5S,8S)-8-[{(1R)-1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one mesylate
951390-96-8
(5S,8S)-8-[{(1R)-1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one oxalate
951390-95-7
(5S,8S)-8-[{(1R)-1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one esylate

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