WIKI4 is , while it's Molecular Formula is C29H23N5O3S. WIKI4 is a novel Tankyrase inhibitor. It leads to inhibition of Wnt/?-catenin signaling.

What is the CAS number for WIKI4?

The CAS number of WIKI4 is 838818-26-1.

What is WIKI4 (838818-26-1) used for?

Tankyrases (TNKS) cleave NAD+ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in the process known as poly(ADP-ribosyl)ation. WIKI4 is a potent and selective inhibitor of TNKS1 and TNKS2 (IC50s = 26 and 15 nM, respectively). It has little or no effect on related polymerases or transferases at 10 μM. Through its effects on TNKS2, WIKI4 prevents AXIN ubiquitinylation and degradation, blocking signaling through the Wnt/β-catenin pathway. WIKI4 inhibits the expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in both cancer cell lines and embryonic stem cells.

WIKI4 is , while it's Molecular Formula is C29H23N5O3S. WIKI4 is a novel Tankyrase inhibitor. It leads to inhibition of Wnt/?-catenin signaling.

What is the CAS number for WIKI4?

The CAS number of WIKI4 is 838818-26-1.

What is WIKI4 (838818-26-1) used for?

Tankyrases (TNKS) cleave NAD+ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in the process known as poly(ADP-ribosyl)ation. WIKI4 is a potent and selective inhibitor of TNKS1 and TNKS2 (IC50s = 26 and 15 nM, respectively). It has little or no effect on related polymerases or transferases at 10 μM. Through its effects on TNKS2, WIKI4 prevents AXIN ubiquitinylation and degradation, blocking signaling through the Wnt/β-catenin pathway. WIKI4 inhibits the expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in both cancer cell lines and embryonic stem cells.

Products

Product classification

small-molecule inhibitor
intermediate
Pharmaceutical intermediate
Biochemical reagent
fire retardant
chemical reagent
ionic liquid
Inhibitor
Antibody
Pesticide
New materials
Customization
Nucleosides
Food additives
Supplement
API
Pharmaceutical intermediates

Contact us

Tel：+86-0533-2185556
Fax：+86-0533-2185556
Phone：WhatsApp: +86 15965530500
Website：https://www.shandonghangyubiotech.com
Email：admin@hangyubiotech.com
Address：Room 2516, Dingcheng Building, Beijing Road, Zhangdian District, Zibo City, Shandong Province

838818-26-1

Product Name:WIKI4
Molecular Formula:C29H23N5O3S
Molecular Weight:521.6

Inquiry

Product Details

Purity:99%

Cost-effective and customizable WIKI4 838818-26-1 in stock

Molecular Formula:C29H23N5O3S
Molecular Weight:521.6
Boiling Point:783.1±70.0 °C(Predicted)
PKA:1.70±0.10(Predicted)
PSA：117.20000
Density:1.37±0.1 g/cm3(Predicted)
LogP:4.78640

Relevant Products

Prasugrel
CAS：115473-15-9
OXACILLIN SODIUM
CAS：1173-88-2
WS3
CAS：1421227-52-2
meso-Tetrakis(4-chlorophenyl)porphyrin-Fe(III)chloride
CAS：36965-70-5

Home

About us

Products

small-molecule inhibitor

intermediate

Pharmaceutical intermediate

Biochemical reagent

fire retardant

chemical reagent

ionic liquid

Inhibitor

Antibody

Pesticide

New materials

Customization

Nucleosides

Food additives

Supplement

API

Pharmaceutical intermediates

Biological products

Polypeptides

Chemical reagents

Small molecule inhibitors

Organic electronic chemical materials

Technical Support

News

Contact Us