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1421227-52-2

  • Product Name:WS3
  • Molecular Formula:C28H30F3N7O3
  • Molecular Weight:569.587
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Product Details

Purity:99%

Cost-effective and customizable WS3 1421227-52-2 for sale

  • Molecular Formula:C28H30F3N7O3
  • Molecular Weight:569.587
  • Boiling Point:632.9±55.0 °C(Predicted) 
  • PKA:11.82±0.20(Predicted) 
  • PSA：111.72000 
  • Density:1.423±0.06 g/cm3(Predicted) 
  • LogP:5.12240 

1421227-52-2 Relevant articles

Small-molecule inducer of β cell proliferation identified by high-throughput screening

Shen, Weijun,Tremblay, Matthew S.,Deshmukh, Vishal A.,Wang, Weidong,Filippi, Christophe M.,Harb, George,Zhang, You-Qing,Kamireddy, Anwesh,Baaten, Janine E,Jin, Qihui,Wu, Tom,Swoboda, Jonathan G.,Cho, Charles Y.,Li, Jing,Laffitte, Bryan A.,McNamara, Peter,Glynne, Richard,Wu, Xu,Herman, Ann E.,Schultz, Peter G.

, p. 1669 - 1672 (2013/04/23)

The identification of factors that promo...

1421227-52-2 Process route

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline
694499-26-8

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline

C<sub>21</sub>H<sub>17</sub>N<sub>5</sub>O<sub>6</sub>

C21H17N5O6

N-(6-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl) ureido) phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide
1421227-52-2

N-(6-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl) ureido) phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide

Conditions
Conditions Yield
With triethylamine; In dichloromethane; at 20 ℃;
824 mg
4-chloro-6-(4-nitro-phenoxy)-pyrimidine
124041-03-8

4-chloro-6-(4-nitro-phenoxy)-pyrimidine

N-(6-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl) ureido) phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide
1421227-52-2

N-(6-(4-(3-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl) ureido) phenoxy)pyrimidin-4-yl)cyclopropanecarboxamide

Conditions
Conditions Yield
Multi-step reaction with 4 steps
1: tris-(dibenzylideneacetone)dipalladium(0); 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 110 °C / Inert atmosphere
2: hydrogen / ethanol / 3 h / 2585.81 Torr
3: pyridine / dichloromethane / 0.5 h
4: triethylamine / dichloromethane / 20 °C
With pyridine; tris-(dibenzylideneacetone)dipalladium(0); hydrogen; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; dichloromethane;

1421227-52-2 Upstream products

  • 124041-03-8
    124041-03-8

    4-chloro-6-(4-nitro-phenoxy)-pyrimidine

  • 1421227-55-5
    1421227-55-5

    N-[6-(4-nitrophenoxyl)pyrimidin-4-yl]cyclopropanecarboxamide

  • 1421227-56-6
    1421227-56-6

    N-[6-(4-aminophenoxyl)pyrimidin-4-yl]cyclopropanecarboxamide

  • 694499-26-8
    694499-26-8

    4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline

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