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64951-58-2

  • Product Name:(4-Chloro-8-methoxy-2-methylquinoline)
  • Molecular Formula:C11H10ClNO
  • Molecular Weight:207.659
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Product Details

pd_meltingpoint:89-93℃

Purity:99%

Buy high quality and low price (4-Chloro-8-methoxy-2-methylquinoline) 64951-58-2 now

  • Molecular Formula:C11H10ClNO
  • Molecular Weight:207.659
  • Vapor Pressure:0.00121mmHg at 25°C 
  • Melting Point:89-93℃ 
  • Refractive Index:1.609 
  • Boiling Point:308.8 °C at 760 mmHg 
  • PKA:2.67±0.50(Predicted) 
  • Flash Point:140.6 °C 
  • PSA:22.12000 
  • Density:1.228 g/cm3 
  • LogP:3.20520 

4-CHLORO-8-METHOXY-2-METHYLQUINOLINE(Cas 64951-58-2) Usage

General Description

4-Chloro-8-methoxy-2-methylquinoline is a chemical compound that belongs to the quinoline family. It is a yellow crystalline solid with a molecular formula of C11H10ClNO. It is used in the pharmaceutical industry as a building block for the synthesis of various drugs and molecules. 4-CHLORO-8-METHOXY-2-METHYLQUINOLINE has also been studied for its potential biological and medicinal properties, including its antimicrobial and antifungal activities. Additionally, it has been investigated for its potential use as an antioxidant and as a fluorescent probe for sensing metal ions. Overall, 4-chloro-8-methoxy-2-methylquinoline is a versatile chemical with a range of potential applications in various fields.

InChI:InChI=1/C11H10ClNO/c1-7-6-9(12)8-4-3-5-10(14-2)11(8)13-7/h3-6H,1-2H3

64951-58-2 Relevant articles

Potent antiproliferative activity of bradykinin B2 receptor selective agonist FR-190997 and analogue structures thereof: A paradox resolved?

Rassias, Gerasimos,Leonardi, Sofia,Rigopoulou, Dionisia,Vachlioti, Eleanna,Afratis, Konstantinos,Piperigkou, Zoi,Koutsakis, Christos,Karamanos, Nikos K.,Gavras, Haralambos,Papaioannou, Dionissios

supporting information, (2020/11/12)

Βradykinin stimulation of B2 receptor is...

Synthesis, SAR study, and bioactivity evaluation of a series of Quinoline-Indole-Schiff base derivatives: Compound 10E as a new Nur77 exporter and autophagic death inducer

Chen, Jingwei,Chen, Kun,Fang, Meijuan,He, Fengming,Huang, Jiangang,Li, Baicun,Lin, Zongxin,Liu, Jie,Liu, Shunzhi,Wang, Wang,Wu, Tong,Yao, Jie,Zeng, Jin-Zhang

, (2021/06/15)

We previously reported 5-((8-methoxy-2-m...

Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators

Li, Baicun,Yao, Jie,Guo, Kaiqiang,He, Fengming,Chen, Kun,Lin, Zongxin,Liu, Shunzhi,Huang, Jiangang,Wu, Qiaoqiong,Fang, Meijuan,Zeng, Jinzhang,Wu, Zhen

, (2020/07/27)

Nur77 is a potential target for the trea...

Synthesis of 6-methoxy-N 2,N 2,N 4,N 4,N 5,N 5-hexamethylquinoline-2,4,5-triamine - A new representative of quinoline proton sponges

Dyablo, Olga V.,Pozharskii, Alexander F.,Shmoilova, Elena A.,Savchenko, Aleksey O.

, p. 250 - 258 (2016/01/12)

[Figure not available: see fulltext.] We...

64951-58-2 Process route

8-methoxy-2-methyl-4-quinolinol
15644-89-0

8-methoxy-2-methyl-4-quinolinol

4-chloro-8-methoxy-2-methylquinoline
64951-58-2

4-chloro-8-methoxy-2-methylquinoline

Conditions
Conditions Yield
With N,N-dimethyl-aniline; trichlorophosphate; for 2h; Heating;
81.9%
With trichlorophosphate; for 3h; Reflux;
81%
With trichlorophosphate; at 130 ℃;
61%
With trichlorophosphate; at 75 ℃;
With trichlorophosphate;
With trichlorophosphate; at 130 ℃; for 4h;
1.26 g
ethyl 3-<(2-methoxyphenyl)amino>but-2-enoate
33267-45-7

ethyl 3-<(2-methoxyphenyl)amino>but-2-enoate

4-chloro-8-methoxy-2-methylquinoline
64951-58-2

4-chloro-8-methoxy-2-methylquinoline

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 48.7 percent / diphenyl ether; various solvent(s) / 3 h / 235 °C
2: 81.9 percent / phosphorus oxychloride; N,N-dimethylaniline / 2 h / Heating
With N,N-dimethyl-aniline; trichlorophosphate; In diphenylether;

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