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247068-85-5

  • Product Name:Carfilzomib amine intermediate
  • Molecular Formula:C9H17NO2.C2HF3O2
  • Molecular Weight:285.26000
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Product Details

pd_meltingpoint:120 - 123° C

Purity:99%

Top Quality Chinese Factory supply 247068-85-5 Carfilzomib amine intermediate

  • Molecular Formula:C9H17NO2.C2HF3O2
  • Molecular Weight:285.26000
  • Melting Point:120 - 123° C 
  • PSA：92.92000 
  • LogP:2.05140 

247068-85-5 Relevant articles

Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes

Verdoes, Martijn,Hillaert, Ulrik,Florea, Bogdan I.,Sae-Heng, Myra,Risseeuw, Martijn D.P.,Filippov, Dmitri V.,van der Marel, Gijsbert A.,Overkleeft, Herman S.

, p. 6169 - 6171 (2007)

The synthesis of three acetylene functio...

Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer's Disease

Lee, Min Jae,Bhattarai, Deepak,Jang, Hyeryung,Baek, Ahreum,Yeo, In Jun,Lee, Seongsoo,Miller, Zachary,Lee, Sukyeong,Hong, Jin Tae,Kim, Dong-Eun,Lee, Wooin,Kim, Kyung Bo

, p. 10934 - 10950 (2021/08/20)

Previously, we reported that immunoprote...

Preparation method of carfilzomib intermediate

-

, (2021/08/06)

The invention relates to a preparation m...

Discovery of novel tripeptide propylene oxide proteasome inhibitors for the treatment of multiple myeloma

Zhang, Wen,Wang, Xueyuan,Zhang, Haoyang,Wen, Tiantian,Yang, Lin,Miao, Hang,Wang, Jia,Liu, Hailong,Yang, Xu,Lei, Meng,Zhu, Yongqiang

supporting information, (2021/05/13)

The ubiquitin proteasome pathway (UPP) p...

Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents

Almaliti, Jehad,Miller, Bailey,Pietraszkiewicz, Halina,Glukhov, Evgenia,Naman, C. Benjamin,Kline, Toni,Hanson, Jeffrey,Li, Xiaofan,Zhou, Sihong,Valeriote, Frederick A.,Gerwick, William H.

, p. 416 - 432 (2018/10/31)

Antibody–drug conjugates (ADCs) represen...

247068-85-5 Process route

tert-butyl [(1S)-3-methyl-1-(2-methylpropyl)-2-oxobut-3-en-1-yl]carbamate
247068-81-1

tert-butyl [(1S)-3-methyl-1-(2-methylpropyl)-2-oxobut-3-en-1-yl]carbamate

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trifluoroacetic acid salt
247068-85-5

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)pentan-1-one trifluoroacetic acid salt

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine; dihydrogen peroxide / methanol / 2 h
2: dichloromethane
With dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
Multi-step reaction with 4 steps
1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.08 h / 0 °C / Inert atmosphere
2: bis(acetylacetonate)oxovanadium; tert.-butylhydroperoxide / dichloromethane / 1 h / 0 °C / Inert atmosphere
3: Dess-Martin periodane / dichloromethane / 3 h / 0 °C / Inert atmosphere
4: dichloromethane / 0.5 h / 20 °C / Inert atmosphere
With tert.-butylhydroperoxide; sodium tetrahydroborate; bis(acetylacetonate)oxovanadium; cerium(III) chloride heptahydrate; Dess-Martin periodane; In methanol; dichloromethane; 2: |Sharpless Asymmetric Epoxidation / 3: |Dess-Martin Oxidation;
Multi-step reaction with 2 steps
1: calcium hypochlorite / water; 1-methyl-pyrrolidin-2-one / 0.33 h / -15 - 0 °C
2: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
With calcium hypochlorite; In 1-methyl-pyrrolidin-2-one; dichloromethane; water;
Multi-step reaction with 2 steps
1: sodium hypochlorite; pyridine / water / 2 h / -5 - 0 °C
2: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
With pyridine; sodium hypochlorite; In dichloromethane; water;
Multi-step reaction with 4 steps
1: cerium(III) chloride heptahydrate; sodium tetrahydroborate / methanol / 1 h / 0 - 5 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 - 30 °C
3: Dess-Martin periodane / acetonitrile / 3 h / 0 - 30 °C
4: dichloromethane / 2 h / 2 - 30 °C
With sodium tetrahydroborate; cerium(III) chloride heptahydrate; Dess-Martin periodane; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; acetonitrile;
Multi-step reaction with 2 steps
1: acetic acid; dihydrogen peroxide; C28H34F6MnN6O6S2 / acetonitrile / 2 h / -20 °C
2: dichloromethane / 4 h / 20 °C
With C28H34F6MnN6O6S2; dihydrogen peroxide; acetic acid; In dichloromethane; acetonitrile;
Multi-step reaction with 4 steps
1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0.42 h / 0 °C
2: bis(acetylacetonate)oxovanadium; tert.-butylhydroperoxide / dichloromethane / 2 h / 0 °C
3: Dess-Martin periodane / dichloromethane / 20 °C
4: dichloromethane / 0.5 h
With tert.-butylhydroperoxide; sodium tetrahydroborate; bis(acetylacetonate)oxovanadium; cerium(III) chloride heptahydrate; Dess-Martin periodane; In methanol; dichloromethane;
Multi-step reaction with 4 steps
1: aluminum isopropoxide; isopropyl alcohol / toluene / 3 h / 50 °C
2: tert.-butylhydroperoxide; tris(acetylacetonato)vanadium(III) / dichloromethane / 12 h / 0 - 20 °C
3: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 6 h
4: dichloromethane / 2 h / 0 - 20 °C
With tert.-butylhydroperoxide; tris(acetylacetonato)vanadium(III); sulfur trioxide pyridine complex; aluminum isopropoxide; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; In dichloromethane; dimethyl sulfoxide; toluene;
tert-butyl [(1S)-3-methyl-1-(2-methylpropyl)-2-oxobut-3-en-1-yl]carbamate
247068-81-1

tert-butyl [(1S)-3-methyl-1-(2-methylpropyl)-2-oxobut-3-en-1-yl]carbamate

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2yl)pentan-1-one trifluoroacetic acid
247068-85-5

(S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2yl)pentan-1-one trifluoroacetic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: urea hydrogen peroxide adduct; tetramethyl ammoniumhydroxide / methanol; benzonitrile / 20 h / -10 °C / Inert atmosphere
2: dichloromethane / 0.5 h / 20 °C
With tetramethyl ammoniumhydroxide; urea hydrogen peroxide adduct; In methanol; dichloromethane; benzonitrile;
Multi-step reaction with 2 steps
1: dihydrogen peroxide; N-ethyl-N,N-diisopropylamine / benzonitrile; methanol / 3 h / 0 °C / Inert atmosphere
2: dichloromethane / 20 °C
With dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; benzonitrile;

247068-85-5 Upstream products

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    trifluoroacetic acid

  • 247068-82-2
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    tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

  • 2018-66-8
    2018-66-8

    Z-Leu-OH

  • 869487-76-3
    869487-76-3

    (S)-benzyl (2,6-dimethyl-3-oxohept-1-en-4-yl)carbamate

247068-85-5 Downstream products

  • 1262241-20-2
    1262241-20-2

    C34H53N5O6

  • 247068-82-2
    247068-82-2

    tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate

  • 868540-17-4
    868540-17-4

    carfilzomib

  • 247068-84-4
    247068-84-4

    (2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]pentan-1-one

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