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1174130-61-0

  • Product Name:Aticaprant
  • Molecular Formula:C26H27FN2O2
  • Molecular Weight:418.511
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Product Details

Purity:99%

Buy Quality Aticaprant 1174130-61-0 In Stock with Immediately Delivery

  • Molecular Formula:C26H27FN2O2
  • Molecular Weight:418.511
  • Boiling Point:519.2±50.0 °C(Predicted) 
  • PKA:15.61±0.50(Predicted) 
  • PSA：56.55000 
  • Density:1.201±0.06 g/cm3(Predicted) 
  • LogP:6.49290 

1174130-61-0 Relevant articles

Discovery of aminobenzyloxyarylamides as κ opioid receptor selective antagonists: Application to preclinical development of a κ opioid receptor antagonist receptor occupancy tracer

Mitch, Charles H.,Quimby, Steven J.,Diaz, Nuria,Pedregal, Concepcion,De La Torre, Marta G.,Jimenez, Alma,Shi, Qing,Canada, Emily J.,Kahl, Steven D.,Statnick, Michael A.,McKinzie, David L.,Benesh, Dana R.,Rash, Karen S.,Barth, Vanessa N.

, p. 8000 - 8012 (2012/01/19)

Arylphenylpyrrolidinylmethylphenoxybenza...

KAPPA SELECTIVE OPIOID RECEPTOR ANTAGONIST

-

Page/Page column 6, (2009/07/25)

A selective kappa opioid receptor antago...

1174130-61-0 Process route

3-fluoro-4-(4-formylphenoxy)benzamide
676494-56-7

3-fluoro-4-(4-formylphenoxy)benzamide

(2S)-2-(3,5-dimethylphenyl)pyrrolidine
1213334-10-1

(2S)-2-(3,5-dimethylphenyl)pyrrolidine

JSPA<sub>06508</sub>
1174130-61-0

JSPA06508

Conditions
Conditions Yield
With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane;
3-fluoro-4-(4-formylphenoxy)benzamide; (2S)-2-(3,5-dimethylphenyl)pyrrolidine; In 1,2-dichloro-ethane; at 20 ℃; Molecular sieve;
With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 3h;
3-fluoro-4-(4-formylphenoxy)benzonitrile
676494-55-6

3-fluoro-4-(4-formylphenoxy)benzonitrile

JSPA<sub>06508</sub>
1174130-61-0

JSPA06508

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: dihydrogen peroxide / water; dimethyl sulfoxide / 2 h / 10 - 20 °C / Alkaline conditions
2.1: 1,2-dichloro-ethane / 20 °C / Molecular sieve
2.2: 3 h / 20 °C
With dihydrogen peroxide; In water; dimethyl sulfoxide; 1,2-dichloro-ethane;

1174130-61-0 Upstream products

  • 1174130-60-9
    1174130-60-9

    4-[4-[[2-(3,5-dimethylphenyl)pyrrolidin-1-yl]methyl]phenoxy]-3-fluorobenzamide

  • 676494-55-6
    676494-55-6

    3-fluoro-4-(4-formylphenoxy)benzonitrile

  • 676494-56-7
    676494-56-7

    3-fluoro-4-(4-formylphenoxy)benzamide

  • 1213334-10-1
    1213334-10-1

    (2S)-2-(3,5-dimethylphenyl)pyrrolidine

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