What is the P7C3-A20?

P7C3-A20 is , while it's Molecular Formula is C22H19Br2FN2O. Used in Pharmaceutical Industry: P7C3-A20 is used as a proneurogenic and neuroprotective agent for promoting neuronal growth and protecting against cell death in various neurological conditions. Used in Neurological Research: P7C3-A20 is used as a research tool for studying the mechanisms underlying neuronal proliferation, neuroprotection, and the treatment of neurological disorders such as traumatic brain injury and Parkinson's disease. Used in Drug Development: P7C3-A20 is used as a potential therapeutic agent for the development of drugs targeting neurological conditions, including traumatic brain injury and neurodegenerative diseases like Parkinson's disease.

What is the CAS number for P7C3-A20?

The CAS number of P7C3-A20 is 1235481-90-9.

What is P7C3-A20 (1235481-90-9) used for?

P7C3-A20 is a derivative of P7C3 (Item No. 16682) that has proneurogenic and neuroprotective activity. It increases proliferation in the subgranular zone (SGZ) of the adult mouse dentate gyrus in a dose-dependent manner when administered at doses ranging from 0.1 to 10 μM. It also protects U2OS cells from calcium-induced mitochondrial dissolution. In a rat model of traumatic brain injury, P7C3-A20 (10 mg/kg, i.p., twice daily for one week) decreases contusion volume, increases proliferation in the SGZ, and decreases the latency to reach the platform in the Morris water maze to sham surgery control levels. It also prevents or reverses dopaminergic cell death and motor deficits in a 6-OHDA rat model of Parkinson's disease.

What is the P7C3-A20?

P7C3-A20 is , while it's Molecular Formula is C22H19Br2FN2O. Used in Pharmaceutical Industry: P7C3-A20 is used as a proneurogenic and neuroprotective agent for promoting neuronal growth and protecting against cell death in various neurological conditions. Used in Neurological Research: P7C3-A20 is used as a research tool for studying the mechanisms underlying neuronal proliferation, neuroprotection, and the treatment of neurological disorders such as traumatic brain injury and Parkinson's disease. Used in Drug Development: P7C3-A20 is used as a potential therapeutic agent for the development of drugs targeting neurological conditions, including traumatic brain injury and neurodegenerative diseases like Parkinson's disease.

What is the CAS number for P7C3-A20?

The CAS number of P7C3-A20 is 1235481-90-9.

What is P7C3-A20 (1235481-90-9) used for?

P7C3-A20 is a derivative of P7C3 (Item No. 16682) that has proneurogenic and neuroprotective activity. It increases proliferation in the subgranular zone (SGZ) of the adult mouse dentate gyrus in a dose-dependent manner when administered at doses ranging from 0.1 to 10 μM. It also protects U2OS cells from calcium-induced mitochondrial dissolution. In a rat model of traumatic brain injury, P7C3-A20 (10 mg/kg, i.p., twice daily for one week) decreases contusion volume, increases proliferation in the SGZ, and decreases the latency to reach the platform in the Morris water maze to sham surgery control levels. It also prevents or reverses dopaminergic cell death and motor deficits in a 6-OHDA rat model of Parkinson's disease.

Product classification

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1235481-90-9

Product Name:P7C3-A20
Molecular Formula:C22H19Br2FN2O
Molecular Weight:506.212

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Product Details

Purity:99%

Bulk supply high purity P7C3-A20 1235481-90-9, Paid sample available

Molecular Formula:C22H19Br2FN2O
Molecular Weight:506.212
Boiling Point:641.3±55.0 °C(Predicted)
PKA:3.25±0.50(Predicted)
PSA：26.19000
Density:1.57±0.1 g/cm3(Predicted)
LogP:6.85130

1235481-90-9 Relevant articles

Pro-neurogenic compounds

-

Page/Page column 97; 98, (2015/09/22)

This invention relates generally to stim...

Development of a scalable synthesis of P7C3-A20, a potent neuroprotective agent

Naidoo, Jacinth,Bemben, Christopher J.,Allwein, Shawn R.,Liang, Jue,Pieper, Andrew A.,Ready, Joseph M.

, p. 4429 - 4431 (2013/07/26)

A scalable synthesis of the neuroprotect...

Development of proneurogenic, neuroprotective small molecules

MacMillan, Karen S.,Naidoo, Jacinth,Liang, Jue,Melito, Lisa,Williams, Noelle S.,Morlock, Lorraine,Huntington, Paula J.,Estill, Sandi Jo,Longgood, Jamie,Becker, Ginger L.,McKnight, Steven L.,Pieper, Andrew A.,De Brabander, Jef K.,Ready, Joseph M.

supporting information; experimental part, p. 1428 - 1437 (2011/04/16)

Degeneration of the hippocampus is assoc...

1235481-90-9 Process route

: 1260172-05-1
N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-N-(3-methoxyphenyl)-4-nitrobenzenesulfonamide

: 1235481-90-9
N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyaniline

Conditions

Conditions	Yield
With mercaptoacetic acid; lithium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;	88%
With mercaptoacetic acid; lithium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 1h;	13.6 mg

: 313268-18-7
1-(3,6-dibromo-9H-carbazol-9-yl)-3-((3-methoxyphenyl)amino)propan-2-ol

: 1235481-90-9
N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-3-methoxyaniline

Conditions

Conditions	Yield
With 4-(trifluoromethyl)morpholine; In dichloromethane;
With diethylamino-sulfur trifluoride; In dichloromethane; at -78 - 0 ℃; for 6h;	5.7 mg

1235481-90-9 Upstream products

1260172-04-0
N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-hydroxypropyl)-N-(3-methoxyphenyl)-4-nitrobenzenesulfonamide
1260172-05-1
N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-N-(3-methoxyphenyl)-4-nitrobenzenesulfonamide
6825-20-3
3,6-dibromo-9H-carbazole
16936-99-5
N-(3-methoxyphenyl)-4-nitrobenzenesulfonamide

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