JW55 is , while it's Molecular Formula is C25H26N2O5. JW-55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin. JW-55 inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. JW-55 reduces cell cycle progression and proliferation in SW480 cells in vitro.

What is the CAS number for JW55?

The CAS number of JW55 is 664993-53-7.

What is JW55 (664993-53-7) used for?

JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC50s = 1.9 and 0.83 μM, respectively). By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of β-catenin, inhibiting the β-catenin signaling pathway (IC50 = 470 nM). It has been shown to decrease canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and to reduce proliferation of SW480 cells in vitro.

JW55 is , while it's Molecular Formula is C25H26N2O5. JW-55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). Activity results in stabilization of Axin2 and increased degradation of β-catenin. JW-55 inhibits the β-catenin signaling pathway. Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. JW-55 reduces cell cycle progression and proliferation in SW480 cells in vitro.

What is the CAS number for JW55?

The CAS number of JW55 is 664993-53-7.

What is JW55 (664993-53-7) used for?

JW 55 is an inhibitor of the PARP domain of tankyrases (TNKS) 1 and 2 (IC50s = 1.9 and 0.83 μM, respectively). By inhibiting TNKS1/2, JW 55 stabilizes Axin2 and increases degradation of β-catenin, inhibiting the β-catenin signaling pathway (IC50 = 470 nM). It has been shown to decrease canonical Wnt signaling in SW480 and HCT15 colon carcinoma cell lines and to reduce proliferation of SW480 cells in vitro.

Product classification

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664993-53-7

Product Name:JW 55
Molecular Formula:C25H26N2O5
Molecular Weight:434.48434

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Product Details

Purity:99%

Manufacturers supply cost-effective and customizable JW 55 664993-53-7

Molecular Formula:C25H26N2O5
Molecular Weight:434.48434
Boiling Point:572.6±50.0 °C(Predicted)
PKA:12.41±0.70(Predicted)
PSA：93.29000
Density:1.235±0.06 g/cm3(Predicted)
LogP:4.79360

664993-53-7 Relevant articles

Synthesis of p-aminobenzoic acid diamides based on 4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-carboxylic acid and [4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]methylamine

Agekyan,Mkryan

, p. 1057 - 1062 (2015/06/25)

Reaction of 4-(4-methoxyphenyl)tetrahydr...

WNT PATHWAY INHIBITORS

-

, (2013/07/05)

Wnt pathway inhibitors A class of compou...

664993-53-7 Process route

: 440087-51-4
1-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]-methylamine

: C₁₂H₈ClNO₃

: 664993-53-7
N-{4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-ylmethylcarbamoyl]phenyl}furan-2-carboxamide

Conditions

Conditions	Yield
With triethylamine; In 1,4-dioxane; at 15 ℃; Reflux;

: 619-45-4
4-methoxycarbonyl aniline

: 664993-53-7
N-{4-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-ylmethylcarbamoyl]phenyl}furan-2-carboxamide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: potassium carbonate / dichloromethane / 20 °C 2: trimethylaluminum / toluene / 2 h / Reflux With trimethylaluminum; potassium carbonate; In dichloromethane; toluene;

664993-53-7 Upstream products

619-45-4
4-methoxycarbonyl aniline
527-69-5
2-furancarbonyl chloride
440087-51-4
1-[4-(4-methoxyphenyl)tetrahydro-2H-pyran-4-yl]-methylamine
313375-40-5
methyl 4-(furan-2-carboxamido)benzoate

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