RG108 is , while it's Molecular Formula is C 19 H 14 N 2 O 4 . RG108 has been used:in reprogramming and increasing cell plasticity of primary multipotent mesenchymal stromal cells (MMSC)as an inhibitor of DNA methyltransferase (DNMTi) in human retinal pigment epithelial ARPE-19 cellsas a DNA methyltransferase inhibitor in C33A2 cells to test its effect on papillomavirus late gene expression (HPV16)

What is the CAS number for RG108?

The CAS number of RG108 is 48208-26-0.

What is RG108 (48208-26-0) used for?

RG-108 (48208-26-0) is a non-nucleoside DNA methyltransferase inhibitor. IC50=115 nM1 Inhibits DNA methylation in human tumor cell lines without toxicity2. RG-108 enhances the reversion of neural progenitor cells to the pluripotent state.3InChI:InChI=1/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1

RG108 is , while it's Molecular Formula is C 19 H 14 N 2 O 4 . RG108 has been used:in reprogramming and increasing cell plasticity of primary multipotent mesenchymal stromal cells (MMSC)as an inhibitor of DNA methyltransferase (DNMTi) in human retinal pigment epithelial ARPE-19 cellsas a DNA methyltransferase inhibitor in C33A2 cells to test its effect on papillomavirus late gene expression (HPV16)

What is the CAS number for RG108?

The CAS number of RG108 is 48208-26-0.

What is RG108 (48208-26-0) used for?

RG-108 (48208-26-0) is a non-nucleoside DNA methyltransferase inhibitor. IC50=115 nM1 Inhibits DNA methylation in human tumor cell lines without toxicity2. RG-108 enhances the reversion of neural progenitor cells to the pluripotent state.3InChI:InChI=1/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1

Product classification

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48208-26-0

Product Name:RG108
Molecular Formula:C19H14 N2 O4
Molecular Weight:334.331

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Product Details

pd_meltingpoint:192-194℃

Purity:99%

Cost-effective and customizable RG108 48208-26-0 factory

Molecular Formula:C₁₉H₁₄N₂O₄
Molecular Weight:334.331
Vapor Pressure:7E-19mmHg at 25°C
Melting Point:192-194℃
Refractive Index:1.723
Boiling Point:670.3°C at 760 mmHg
PKA:3.62±0.10(Predicted)
Flash Point:359.2°C
PSA：90.47000
Density:1.47g/cm³
LogP:2.39770

RG108(Cas 48208-26-0) Usage

Biological Activity	Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes.
Biochem/physiol Actions	RG108 is a DNA methyltransferase (DMNT) inhibitor. It reactivates tumor suppressor gene expression (p16, SFRP1, secreted frizzled related protein-1, and TIMP-3) in tumor cells by DNA demethylation. RG108 also inhibits human tumor cell line (HCT116, NALM-6) proliferation and increased doubling time in culture.
General Description	RG108, a non-nucleoside analog is also called [2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl) propanoic acid.

InChI:InChI=1/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1

48208-26-0 Relevant articles

Convergent Synthesis of Calcium-Dependent Antibiotic CDA3a and Analogues with Improved Antibacterial Activity via Late-Stage Serine Ligation

Blasco, Pilar,Chen, Delin,Chen, Sheng,Li, Xuechen,Po, Kathy Hiu Laam

supporting information, (2020/06/29)

A convergent synthesis via the late-stag...

Chiral sensors for determining the absolute configurations of α-amino acid derivatives

Chen, Zhongxiang,Fan, Hongjun,Yang, Shiwei,Bian, Guangling,Song, Ling

, p. 6933 - 6939 (2018/10/02)

A simple strategy for configurational as...

Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1

Asgatay, Saa?dia,Champion, Christine,Marloie, Ga?l,Drujon, Thierry,Senamaud-Beaufort, Catherine,Ceccaldi, Alexandre,Erdmann, Alexandre,Rajavelu, Arumugam,Schambel, Philippe,Jeltsch, Albert,Lequin, Olivier,Karoyan, Philippe,Arimondo, Paola B.,Guianvarc'H, Dominique

, p. 421 - 434 (2014/02/14)

DNA methyltransferases (DNMT) are promis...

Phthaloyl amino acids as anti-inflammatory and immunomodulatory prototypes

Leite, Ana Cristina Lima,Barbosa, Fabio Fernandes,Cardoso, Marcos Verissimo De Oliveira,Moreira, Diogo R. M.,Coelho, Lucas Cunha D.,Da Silva, Elany Barbosa,Filho, Gevanio Bezerra De Oliveira,De Souza, Valdenia Maria Oliveira,Pereira, Valeria Rego A.,Reis, Luiza De C.,Ferreira, Paulo Michel Pinheiro,Pessoa, Claudia,Wanderley, Almir Goncalves,Mota, Fernanda Virginia B.,Da Silva, Teresinha G.

, p. 1701 - 1708 (2014/05/06)

A series of phthalimide analogs were syn...

48208-26-0 Process route

: 22509-74-6
N-ethoxycarbonylphthalimide

: 73-22-3,27732-43-0,80206-30-0,27813-82-7
L-Tryptophan

: 32675-71-1,48208-26-0,62361-30-2
N-phthalimide-L-tryptophan

Conditions

Conditions	Yield
L-Tryptophan; With sodium carbonate; In water; N-ethoxycarbonylphthalimide; In water; at 20 ℃; for 2h;	98%
With sodium carbonate; In water; at 20 ℃; for 1h;	95%
With sodium carbonate; In water; at 20 ℃; for 5h;

: 73-22-3,27732-43-0,80206-30-0,27813-82-7
L-Tryptophan

: 438470-19-0
methyl 2-(N-succinimidyloxycarbonyl)benzoate

: 32675-71-1,48208-26-0,62361-30-2
N-phthalimide-L-tryptophan

Conditions

Conditions	Yield
L-Tryptophan; methyl 2-(N-succinimidyloxycarbonyl)benzoate; With sodium carbonate; In water; acetonitrile; With hydrogenchloride; In water; acetonitrile;	100%
With sodium carbonate; In water; acetonitrile;	100%
With sodium carbonate; In water; acetonitrile; at 20 ℃;	26%
L-Tryptophan; methyl 2-(N-succinimidyloxycarbonyl)benzoate; With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 3h; With hydrogenchloride; In water; N,N-dimethyl-formamide; Product distribution / selectivity;

48208-26-0 Upstream products

85-44-9
phthalic anhydride
73-22-3
L-Tryptophan
6159-33-7
L-tryptophan hydrochloride
438470-19-0
methyl 2-(N-succinimidyloxycarbonyl)benzoate

48208-26-0 Downstream products

883556-44-3
benzyl (S)-N-phthaloyltryptophanyl-(S)-prolinate
883556-51-2
C₆₈H₇₆N₁₀O₁₃S
1194630-01-7
C₂₆H₁₉FN₂O₄
1194629-99-6
N-Phth-Trp-Phe-OMe

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