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pd_meltingpoint:320 °C (decomp)
Purity:99%
InChI:InChI=1/C16H13FN2O3/c1-7-13(18-8(2)14(7)16(21)22)6-11-10-5-9(17)3-4-12(10)19-15(11)20/h3-6,18H,1-2H3,(H,19,20)(H,21,22)/b11-6-
The present disclosure relates to compou...
The present disclosure relates to compou...
Dendrimer compositions and methods for t...
AMP-activated protein kinase (AMPK) is a...
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
5-fluoroindol-2(3H)-one
5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
| Conditions | Yield |
|---|---|
|
5-fluoroindol-2(3H)-one;
With
anhydrous ammonium sulphate; 1,1,1,3,3,3-hexamethyl-disilazane;
for 5h;
Reflux;
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid;
With
trimethylsilyl trifluoropmethanesulfonate;
|
97% |
|
pyrrolidine;
In
ethanol;
for 3h;
Heating / reflux;
|
96% |
|
With
pyrrolidine;
In
ethanol;
for 3h;
Heating / reflux;
|
96% |
|
With
pyrrolidine;
In
ethanol;
for 3h;
Heating / reflux;
|
93% |
|
With
pyrrolidine;
In
ethanol;
for 3h;
Heating / reflux;
|
93% |
|
5-fluoroindol-2(3H)-one;
With
anhydrous ammonium sulphate; 1,1,1,3,3,3-hexamethyl-disilazane;
In
acetonitrile;
for 5h;
Reflux;
With
5-fluoro-1-(trimethylsilyl)-2-(trimethylsilyloxy)-1H-indole; 1,1,1,3,3,3-hexamethyl-disilazane;
In
acetonitrile;
at 45 ℃;
for 0.25h;
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid;
With
trimethylsilyl trifluoropmethanesulfonate;
In
acetonitrile;
|
91% |
|
With
pyrrolidine;
In
ethanol;
for 3h;
Reflux;
|
91% |
|
With
pyrrolidine;
In
ethanol;
for 3h;
Reflux;
|
91% |
|
With
pyrrolidine;
In
ethanol;
for 3h;
Reflux;
|
91% |
|
With
pyrrolidine;
In
ethanol;
at 80 ℃;
for 3h;
|
82% |
|
With
piperidine;
In
ethanol;
at 60 ℃;
|
80% |
|
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid; 5-fluoroindol-2(3H)-one;
With
pyrrolidine;
In
ethanol;
for 4.5h;
Heating / reflux;
With
acetic acid;
In
ethanol;
for 0.5h;
Heating / reflux;
With
hydrogenchloride;
In
water monomer; acetone;
for 2.16667h;
|
79% |
|
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid; 5-fluoroindol-2(3H)-one;
With
pyrrolidine;
In
ethanol;
for 4.5h;
Heating / reflux;
With
acetic acid;
In
ethanol;
for 0.5h;
Heating / reflux;
|
79% |
|
With
piperidine;
In
ethanol;
for 3h;
Reflux;
|
79.2% |
|
With
pyrrolidine;
In
ethanol;
at 78 ℃;
for 6h;
|
77% |
|
In
pyrrolidine; ethanol;
at 78 ℃;
for 6h;
|
77% |
|
With
piperidine;
In
ethanol;
at 60 ℃;
|
|
|
With
piperidine;
In
ethanol;
at 60 ℃;
|
|
|
5-fluoroindol-2(3H)-one;
With
1,1,1,3,3,3-hexamethyl-disilazane;
ammonium sulphate;
for 5h;
Reflux;
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid;
trimethylsilyl trifluoropmethanesulfonate;
|
pyrrolidine
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
5-fluoroindol-2(3H)-one
5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; acetic acid;
In
ethanol; water; acetone;
|
79% |
|
With
hydrogenchloride; acetic acid;
In
ethanol; water; acetone;
|
79% |
|
With
hydrogenchloride; acetic acid;
In
ethanol; water; acetone;
|
79% |
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid
5-fluoroindol-2(3H)-one
ethyl (5-formyl-2,4-dimethyl-1H-pyrrole)-3-carboxylate
2-tert-butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
(Z)-N-(2-(dimethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide
sunitinib
(Z)-methyl 4-(2-(5-((5-fluoro-2-oxo-indolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamido)ethoxy)benzoate
methyl (E)-3-(4-(2-(5-((Z)-(5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamido)ethoxy)phenyl)acrylate
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