What is the Mal-PEG2-alcohol?

Mal-PEG2-alcohol is , while it's Molecular Formula is C8H11NO4. Used in Pharmaceutical Industry: Mal-PEG2-alcohol is used as a molecular linker for improving the solubility and stability of therapeutic biomolecules. Its ability to form covalent bonds with thiol groups allows for the attachment of drugs or other bioactive molecules to the PEG chain, potentially enhancing their pharmacokinetic properties and reducing immunogenicity. Used in Drug Delivery Systems: In the field of drug delivery, Mal-PEG2-alcohol serves as a key component in the design of targeted drug carriers. The maleimide group can be utilized to attach drug molecules or targeting ligands to the PEGylated carrier, enabling selective delivery to specific cells or tissues. This targeted approach can improve the efficacy of the drug and reduce side effects. Used in Bioconjugation: Mal-PEG2-alcohol is used as a bioconjugation agent to covalently link biomolecules, such as proteins or peptides, with a thiol group to other molecules or surfaces. This can be particularly useful in the development of biosensors, immobilized enzymes, or antibody-drug conjugates. Used in Cosmetics Industry: In the cosmetics industry, Mal-PEG2-alcohol is used as a solubility enhancer for hydrophobic active ingredients. The hydrophilic PEG spacer can improve the dispersion and stability of these ingredients in cosmetic formulations, ensuring their effectiveness and ease of application. Used in Diagnostics: Mal-PEG2-alcohol can be employed in the development of diagnostic tools, such as imaging agents or affinity reagents. The ability to form covalent bonds with thiol-containing biomolecules allows for the creation of stable conjugates that can be used for detecting specific targets in biological samples.

What is the CAS number for Mal-PEG2-alcohol?

The CAS number of Mal-PEG2-alcohol is 34321-81-8.

What is Mal-PEG2-alcohol (34321-81-8) used for?

Mal-PEG2-alcohol is a PEG linker containing a maleimide group and a hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

What is the Mal-PEG2-alcohol?

Mal-PEG2-alcohol is , while it's Molecular Formula is C8H11NO4. Used in Pharmaceutical Industry: Mal-PEG2-alcohol is used as a molecular linker for improving the solubility and stability of therapeutic biomolecules. Its ability to form covalent bonds with thiol groups allows for the attachment of drugs or other bioactive molecules to the PEG chain, potentially enhancing their pharmacokinetic properties and reducing immunogenicity. Used in Drug Delivery Systems: In the field of drug delivery, Mal-PEG2-alcohol serves as a key component in the design of targeted drug carriers. The maleimide group can be utilized to attach drug molecules or targeting ligands to the PEGylated carrier, enabling selective delivery to specific cells or tissues. This targeted approach can improve the efficacy of the drug and reduce side effects. Used in Bioconjugation: Mal-PEG2-alcohol is used as a bioconjugation agent to covalently link biomolecules, such as proteins or peptides, with a thiol group to other molecules or surfaces. This can be particularly useful in the development of biosensors, immobilized enzymes, or antibody-drug conjugates. Used in Cosmetics Industry: In the cosmetics industry, Mal-PEG2-alcohol is used as a solubility enhancer for hydrophobic active ingredients. The hydrophilic PEG spacer can improve the dispersion and stability of these ingredients in cosmetic formulations, ensuring their effectiveness and ease of application. Used in Diagnostics: Mal-PEG2-alcohol can be employed in the development of diagnostic tools, such as imaging agents or affinity reagents. The ability to form covalent bonds with thiol-containing biomolecules allows for the creation of stable conjugates that can be used for detecting specific targets in biological samples.

What is the CAS number for Mal-PEG2-alcohol?

The CAS number of Mal-PEG2-alcohol is 34321-81-8.

What is Mal-PEG2-alcohol (34321-81-8) used for?

Mal-PEG2-alcohol is a PEG linker containing a maleimide group and a hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

Product classification

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34321-81-8

Product Name:Mal-PEG2-alcohol
Molecular Formula:C8H11NO4
Molecular Weight:185.18

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Product Details

Purity:99%

High Quality Chinese Manufacturer supply 34321-81-8 Mal-PEG2-alcohol

Molecular Formula:C8H11NO4
Molecular Weight:185.18
Boiling Point:361.7±22.0 °C(Predicted)
PKA:14.35±0.10(Predicted)
PSA：66.84000
Density:1.317±0.06 g/cm3(Predicted)
LogP:-1.14180

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Antibody-drug conjugates (ADCs) that are...

34321-81-8 Process route

: 55750-48-6
N-methoxycarbonylmaleimide

: 929-06-6
2-(2-Aminoethoxy)ethanol

: 34321-81-8
1-(2-(2-hydroxyethoxy)ethyl)-1H-pyrrole-2,5-dione

Conditions

Conditions	Yield
With sodium hydrogencarbonate; at 0 - 23 ℃; for 1h;	93%
With sodium hydrogencarbonate; In water; at 0 - 20 ℃; for 0.833333h;	90%
With sodium hydrogencarbonate; In water; at 0 - 20 ℃; for 1.16667h;	73%
With sodium hydrogencarbonate;	61%
With sodium hydrogencarbonate; In water; at 0 - 20 ℃;	57%
With sodium hydrogencarbonate; In water; at 0 - 20 ℃; for 3.5h;	53%
With sodium hydrogencarbonate; In water; at 0 - 20 ℃; for 0.833333h; Inert atmosphere;	44%
With sodium hydrogencarbonate; at 0 - 20 ℃;	4.37 g

: 916852-34-1
N-[2-(2-hydroxyethoxy)ethyl]-exo-3,6-epoxy-1,2,3,6-tetrahydrophthalimide

: 34321-81-8
1-(2-(2-hydroxyethoxy)ethyl)-1H-pyrrole-2,5-dione

Conditions

Conditions	Yield
In toluene; for 7h; Reflux;	41%

34321-81-8 Upstream products

55750-48-6
N-methoxycarbonylmaleimide
929-06-6
2-(2-Aminoethoxy)ethanol
55750-49-7
N-ethoxycarbonylmaleinimide
916852-34-1
N-[2-(2-hydroxyethoxy)ethyl]-exo-3,6-epoxy-1,2,3,6-tetrahydrophthalimide

34321-81-8 Downstream products

872356-55-3
2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)acetaldehyde
872356-56-4
1-[2-(2-{(2S,3S,4S,6R)-3-Hydroxy-2-methyl-6-[(1S,3S)-3,5,12-trihydroxy-3-(2-hydroxy-acetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-1-yloxy]-tetrahydro-pyran-4-ylamino}-ethoxy)-ethyl]-pyrrole-2,5-dione
1050217-24-7
2-dodecylsulfanylthiocarbonylsulfanyl-2-methylpropionic acid maleimido ethoxyethyl ester
97725-90-1
4-<2-Diaethylphosphono-vinyl>-cyclohexen-1-phosphonsaeure-(3)-diaethylester

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