PFK-015 is , while it's Molecular Formula is C 17 H 12 N 2 O. Used in Anticancer Applications: PFK-015 is used as an anticancer agent for targeting the high glycolytic rate in neoplastic cells. By inhibiting PFKFB3, it disrupts the Warburg Effect, which is a metabolic hallmark of cancer cells. This inhibition leads to reduced glucose and F26BP uptake, inducing apoptosis and subsequently reducing tumor growth in various cancer models. Used in Drug Development: PFK-015 is used as a lead compound in the development of novel cancer therapeutics. Its high specificity for PFKFB3 and minimal off-target effects on other kinases make it an attractive candidate for further research and potential clinical applications. Used in Cancer Research: PFK-015 is used as a research tool to study the role of PFKFB3 in cancer metabolism and the Warburg Effect. It can help researchers understand the underlying mechanisms of cancer cell metabolism and identify potential targets for therapeutic intervention. Used in Drug Delivery Systems: PFK-015 can be used in the development of drug delivery systems to improve its bioavailability, delivery, and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the efficacy of PFK-015 against cancer cells can be enhanced, potentially leading to more effective cancer treatments.

What is the CAS number for PFK-015?

The CAS number of PFK-015 is 4382-63-2.

What is PFK-015 (4382-63-2) used for?

PFK15 (4382-63-2) is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3).? PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. PFK15 inhibits PFKFB3 (IC50?= 207 nM) without inhibiting 96 other kinases.1?PFK15 was able to potently inhibit glucose and F26BP uptake. It induced apoptosis and reduced tumor growth?in vitro?and?in vivo.?PFK15 has been shown to inhibit tumor growth in various cancer models.2,3

PFK-015 is , while it's Molecular Formula is C 17 H 12 N 2 O. Used in Anticancer Applications: PFK-015 is used as an anticancer agent for targeting the high glycolytic rate in neoplastic cells. By inhibiting PFKFB3, it disrupts the Warburg Effect, which is a metabolic hallmark of cancer cells. This inhibition leads to reduced glucose and F26BP uptake, inducing apoptosis and subsequently reducing tumor growth in various cancer models. Used in Drug Development: PFK-015 is used as a lead compound in the development of novel cancer therapeutics. Its high specificity for PFKFB3 and minimal off-target effects on other kinases make it an attractive candidate for further research and potential clinical applications. Used in Cancer Research: PFK-015 is used as a research tool to study the role of PFKFB3 in cancer metabolism and the Warburg Effect. It can help researchers understand the underlying mechanisms of cancer cell metabolism and identify potential targets for therapeutic intervention. Used in Drug Delivery Systems: PFK-015 can be used in the development of drug delivery systems to improve its bioavailability, delivery, and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the efficacy of PFK-015 against cancer cells can be enhanced, potentially leading to more effective cancer treatments.

What is the CAS number for PFK-015?

The CAS number of PFK-015 is 4382-63-2.

What is PFK-015 (4382-63-2) used for?

PFK15 (4382-63-2) is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3).? PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. PFK15 inhibits PFKFB3 (IC50?= 207 nM) without inhibiting 96 other kinases.1?PFK15 was able to potently inhibit glucose and F26BP uptake. It induced apoptosis and reduced tumor growth?in vitro?and?in vivo.?PFK15 has been shown to inhibit tumor growth in various cancer models.2,3

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